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10.1016/j.celrep.2017.01.059 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.01.059 C5492976!5492976!28199839     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2017 ; 18 (7): 1660-73 Nephropedia Template TP {{tp|p=28199839|t=2017. The survival of motor neuron protein acts as a molecular chaperone for mRNP assembly |pdf=|usr=}}{{28199839}} gab.com Text The survival of motor neuron protein acts as a molecular chaperone for mRNP assembly JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28199839 #FOAvip Spinal muscular atrophy (SMA) is a motor neuron disease caused by reduced levels of the survival of motor neuron (SMN) protein. SMN is part of a multiprotein complex that facilitates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). SMN has also been found to associate with mRNA binding proteins but the nature of this association was unknown. Here we have employed a combination of biochemical and advanced imaging methods to demonstrate that SMN promotes the molecular interaction between IMP1 protein and the 3? UTR zipcode region of ?-actin mRNA, leading to assembly of messenger ribonucleoprotein complexes (mRNPs) that associate with the cytoskeleton to facilitate trafficking. We have identified defects in mRNP assembly in cells and tissues from SMA disease models and patients that depend on the SMN Tudor domain and explain the observed deficiency in mRNA localization and local translation, providing insight into SMA pathogenesis as an RNP-assembly disorder. Twit Text FOAVip The survival of motor neuron protein acts as a molecular chaperone for mRNP assembly ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28199839 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28199839 #FOAvip English Wikipedia <ref>{{Cite pmid|28199839}}</ref> The survival of motor neuron protein acts as a molecular chaperone for mRNP assembly #MMPMID28199839 Donlin-Asp PG; Fallini C; Campos J; Chou CC; Merritt ME; Phan HC; Bassell GJ; Rossoll W Cell Rep 2017[Feb]; 18 (7): 1660-73 PMID28199839show ga Spinal muscular atrophy (SMA) is a motor neuron disease caused by reduced levels of the survival of motor neuron (SMN) protein. SMN is part of a multiprotein complex that facilitates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). SMN has also been found to associate with mRNA binding proteins but the nature of this association was unknown. Here we have employed a combination of biochemical and advanced imaging methods to demonstrate that SMN promotes the molecular interaction between IMP1 protein and the 3? UTR zipcode region of ?-actin mRNA, leading to assembly of messenger ribonucleoprotein complexes (mRNPs) that associate with the cytoskeleton to facilitate trafficking. We have identified defects in mRNP assembly in cells and tissues from SMA disease models and patients that depend on the SMN Tudor domain and explain the observed deficiency in mRNA localization and local translation, providing insight into SMA pathogenesis as an RNP-assembly disorder. äThe survival of motor neuron protein acts as a molecular chaperone for(epmc).pdf DeepDyve Pubget Overpricing