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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Immunol 2016 ; 37 (11): 764-77 Nephropedia Template TP
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Regulation of Lymph Node Vascular-Stromal Compartment by Dendritic Cells #MMPMID27638128
Dasoveanu DC; Shipman WD; Chia JJ; Chyou S; Lu TT
Trends Immunol 2016[Nov]; 37 (11): 764-77 PMID27638128show ga
During normal and pathologic immune responses, lymph nodes can swell considerably. The lymph node vascular-stromal compartment supports and regulates the developing immune responses and undergoes dynamic expansion and remodeling. Recent studies have shown that dendritic cells (DCs), best known for their antigen presentation roles, can directly regulate the vascular-stromal compartment, pointing to a new perspective on DCs as facilitators of lymphoid tissue function. Here, we review the phases of lymph node vascular-stromal growth and remodeling during immune responses, discuss the roles of DCs, and discuss how this understanding can potentially be used for developing novel therapeutic approaches.