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10.3389/fphys.2017.00452 http://scihub22266oqcxt.onion/10.3389/fphys.2017.00452 C5492353!5492353 !28713283     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28713283 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Physiol 2017 ; 8 (ä): 452 Nephropedia Template TP {{tp|p=28713283 |t=2017. Excitatory Modulation of the preBötzinger Complex Inspiratory Rhythm Generating Network by Endogenous Hydrogen Sulfide |pdf=|usr=}}{{28713283 }} gab.com Text Excitatory Modulation of the preBötzinger Complex Inspiratory Rhythm Generating Network by Endogenous Hydrogen Sulfide JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28713283 #FOAvip Hydrogen Sulfide (H(2)S) is one of three gasotransmitters that modulate excitability in the CNS. Global application of H(2)S donors or inhibitors of H(2)S synthesis to the respiratory network has suggested that inspiratory rhythm is modulated by exogenous and endogenous H(2)S. However, effects have been variable, which may reflect that the RTN/pFRG (retrotrapezoid nucleus, parafacial respiratory group) and the preBötzinger Complex (preBötC, critical for inspiratory rhythm generation) are differentially modulated by exogenous H(2)S. Importantly, site-specific modulation of respiratory nuclei by H(2)S means that targeted, rather than global, manipulation of respiratory nuclei is required to understand the role of H(2)S signaling in respiratory control. Thus, our aim was to test whether endogenous H(2)S, which is produced by cystathionine-?-synthase (CBS) in the CNS, acts specifically within the preBötC to modulate inspiratory activity under basal (in vitro/in vivo) and hypoxic conditions (in vivo). Inhibition of endogenous H(2)S production by bath application of the CBS inhibitor, aminooxyacetic acid (AOAA, 0.1-1.0 mM) to rhythmic brainstem spinal cord (BSSC) and medullary slice preparations from newborn rats, or local application of AOAA into the preBötC (slices only) caused a dose-dependent decrease in burst frequency. Unilateral injection of AOAA into the preBötC of anesthetized, paralyzed adult rats decreased basal inspiratory burst frequency, amplitude and ventilatory output. AOAA in vivo did not affect the initial hypoxia-induced (10% O(2), 5 min) increase in ventilatory output, but enhanced the secondary hypoxic respiratory depression. These data suggest that the preBötC inspiratory network receives tonic excitatory modulation from the CBS-H(2)S system, and that endogenous H(2)S attenuates the secondary hypoxic respiratory depression. Twit Text FOAVip Excitatory Modulation of the preBötzinger Complex Inspiratory Rhythm Generating Network by Endogenous Hydrogen Sulfide ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28713283 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28713283 #FOAvip English Wikipedia <ref>{{Cite pmid|28713283 }}</ref> Excitatory Modulation of the preBötzinger Complex Inspiratory Rhythm Generating Network by Endogenous Hydrogen Sulfide #MMPMID28713283 da Silva GSF ; Sabino JPJ ; Rajani V ; Alvares TS ; Pagliardini S ; Branco LGS ; Funk GD Front Physiol 2017[]; 8 (ä): 452 PMID28713283 show ga Hydrogen Sulfide (H(2)S) is one of three gasotransmitters that modulate excitability in the CNS. Global application of H(2)S donors or inhibitors of H(2)S synthesis to the respiratory network has suggested that inspiratory rhythm is modulated by exogenous and endogenous H(2)S. However, effects have been variable, which may reflect that the RTN/pFRG (retrotrapezoid nucleus, parafacial respiratory group) and the preBötzinger Complex (preBötC, critical for inspiratory rhythm generation) are differentially modulated by exogenous H(2)S. Importantly, site-specific modulation of respiratory nuclei by H(2)S means that targeted, rather than global, manipulation of respiratory nuclei is required to understand the role of H(2)S signaling in respiratory control. Thus, our aim was to test whether endogenous H(2)S, which is produced by cystathionine-?-synthase (CBS) in the CNS, acts specifically within the preBötC to modulate inspiratory activity under basal (in vitro/in vivo) and hypoxic conditions (in vivo). Inhibition of endogenous H(2)S production by bath application of the CBS inhibitor, aminooxyacetic acid (AOAA, 0.1-1.0 mM) to rhythmic brainstem spinal cord (BSSC) and medullary slice preparations from newborn rats, or local application of AOAA into the preBötC (slices only) caused a dose-dependent decrease in burst frequency. Unilateral injection of AOAA into the preBötC of anesthetized, paralyzed adult rats decreased basal inspiratory burst frequency, amplitude and ventilatory output. AOAA in vivo did not affect the initial hypoxia-induced (10% O(2), 5 min) increase in ventilatory output, but enhanced the secondary hypoxic respiratory depression. These data suggest that the preBötC inspiratory network receives tonic excitatory modulation from the CBS-H(2)S system, and that endogenous H(2)S attenuates the secondary hypoxic respiratory depression. äExcitatory Modulation of the preBötzinger Complex Inspiratory Rhythm G(epmc).pdf DeepDyve Pubget Overpricing