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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Physiol+Rep 2017 ; 5 (12): ä Nephropedia Template TP
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Highly suggestive preliminary evidence that the renal interstitium contracts in vivo #MMPMID28646097
Physiol Rep 2017[Jun]; 5 (12): ä PMID28646097show ga
To learn more about controlling renal interstitial hydrostatic pressure (RIHP), we assessed its response to renal medullary direct interstitial volume expansion (rmDIVE = 100 ?L bolus infusion/30 sec). Three experimental series (S) were performed in hydropenic, anesthetized, right?nephrectomized, acute left renal?denervated and renal perfusion pressure?controlled rats randomly assigned to groups in each S. S1: Rats without hormonal clamp were contrasted before and after rmDIVE induced via 0.9% saline solution bolus (SS group) or 2% albumin in SS bolus (2% ALB + SS group). Subcapsular ?RIHP rose slowly, progressively and similarly in both groups by ~3 mmHg. S2: Rats under hormonal clamp were contrasted before and after sham rmDIVE (time CTR group) and real rmDIVE induced via either SS bolus (SS group) or SS bolus containing the subcutaneous tissue fibroblast relaxant dibutyryl?cAMP (SS + db?cAMP group). ?RIHP showed time, group, and time*group interaction effects with a biphasic response (early: ~1 mmHg; late: ~4 mmHg) in the SS group that was absent in the SS + db?cAMP group. S3: Two groups of rats (SS and SS + db?cAMP) under hormonal clamp were contrasted as in S2, producing similar ?RIHP results to those of S2 but showing a slow, progressive, and indistinct decrease in renal outer medullary blood flow in both groups. These results provide highly suggestive preliminary evidence that the renal interstitium is capable of contracting reactively in vivo in response to rmDIVE with SS and demonstrate that such a response is abolished when db?cAMP is interstitially and concomitantly infused.