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10.3389/fimmu.2017.00767 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00767 C5491937!5491937!28713385     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28713385|t=2017. Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering |pdf=|usr=}}{{28713385}} gab.com Text Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28713385 #FOAvip Tertiary lymphoid structures (TLSs) have been identified in the parenchyma and/or in the peripheral margins of human solid tumors. Uncovering the functional nature of these structures is the subject of much intensive investigation. Studies have shown a direct correlation of the presence of human tumor-localized TLS and better patient outcome (e.g., increase in overall survival) in certain solid tumor histologies, but not all. We had identified a tumor-derived immune gene-expression signature, encoding 12 distinct chemokines, which could reliably identify the presence of TLSs, of different degrees, in various human solid tumors. We are focused on understanding the influence of TLSs on the tumor microenvironment and leveraging this understanding to both manipulate the antitumor immune response and potentially enhance immunotherapy applications. Moreover, as not all human solid tumors show the presence of these lymphoid structures, we are embarking on bioengineering approaches to design and build ?designer? TLSs to address, and potentially overcome, an unmet medical need in cancer patients whose tumors lack such lymphoid structures. Twit Text FOAVip Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28713385 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28713385 #FOAvip English Wikipedia <ref>{{Cite pmid|28713385}}</ref> Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering #MMPMID28713385 Zhu G; Falahat R; Wang K; Mailloux A; Artzi N; Mulé JJ Front Immunol 2017[]; 8 (ä): ä PMID28713385show ga Tertiary lymphoid structures (TLSs) have been identified in the parenchyma and/or in the peripheral margins of human solid tumors. Uncovering the functional nature of these structures is the subject of much intensive investigation. Studies have shown a direct correlation of the presence of human tumor-localized TLS and better patient outcome (e.g., increase in overall survival) in certain solid tumor histologies, but not all. We had identified a tumor-derived immune gene-expression signature, encoding 12 distinct chemokines, which could reliably identify the presence of TLSs, of different degrees, in various human solid tumors. We are focused on understanding the influence of TLSs on the tumor microenvironment and leveraging this understanding to both manipulate the antitumor immune response and potentially enhance immunotherapy applications. Moreover, as not all human solid tumors show the presence of these lymphoid structures, we are embarking on bioengineering approaches to design and build ?designer? TLSs to address, and potentially overcome, an unmet medical need in cancer patients whose tumors lack such lymphoid structures. äTumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profili(epmc).pdf DeepDyve Pubget Overpricing