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10.3389/fimmu.2017.00740 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00740 C5491902!5491902 !28713373     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28713373 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Immunol 2017 ; 8 (ä): 740 Nephropedia Template TP {{tp|p=28713373 |t=2017. 15-Deoxy-Delta-12,14-Prostaglandin J(2) Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma |pdf=|usr=}}{{28713373 }} gab.com Text 15-Deoxy-Delta-12,14-Prostaglandin J(2) Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28713373 #FOAvip 15-deoxy-?-12,14-prostaglandin J(2) (15d-PGJ(2)) has been described as an anti-inflammatory lipid mediator in several in vitro and in vivo studies, but its effect on allergic pulmonary inflammation remains elusive. The aim of this study was to investigate the therapeutic potential of 15d-PGJ(2) based on distinct murine models of allergic asthma triggered by either ovalbumin (OVA) or house dust mite extract (HDM). Characteristics of lung inflammation, airway hyper-reactivity (AHR), mucus exacerbation, and lung remodeling in sensitized A/J mice treated or not with 15d-PGJ(2) were assessed. 15d-PGJ(2) treatments were carried out systemically or topically given via subcutaneous injection or intranasal instillation, respectively. Analyses were carried out 24?h after the last allergen provocation. Irrespective of the route of administration, 15d-PGJ(2) significantly inhibited the peribronchial accumulation of eosinophils and neutrophils, subepithelial fibrosis and also mucus exacerbation caused by either OVA or HDM challenge. The protective effect of 15d-PGJ(2) occurred in parallel with inhibition of allergen-induced AHR and lung tissue production of pro-inflammatory cytokines, such as interleukin (IL)-5, IL-13, IL-17, and TNF-?. Finally, 15d-PGJ(2) was found effective in inhibiting NF-?B phosphorylation upon HDM challenge as measured by Western blotting. In conclusion, our findings suggest that 15d-PGJ(2) can reduce crucial features of asthma, including AHR, lung inflammation, and remodeling in distinct murine models of the disease. These effects are associated with a decrease in lung tissue generation of pro-inflammatory cytokines by a mechanism related to downregulation of NF-?B phosphorylation. Twit Text FOAVip 15-Deoxy-Delta-12,14-Prostaglandin J(2) Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28713373 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28713373 #FOAvip English Wikipedia <ref>{{Cite pmid|28713373 }}</ref> 15-Deoxy-Delta-12,14-Prostaglandin J(2) Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma #MMPMID28713373 Coutinho DS ; Anjos-Valotta EA ; do Nascimento CVMF ; Pires ALA ; Napimoga MH ; Carvalho VF ; Torres RC ; E Silva PMR ; Martins MA Front Immunol 2017[]; 8 (ä): 740 PMID28713373 show ga 15-deoxy-?-12,14-prostaglandin J(2) (15d-PGJ(2)) has been described as an anti-inflammatory lipid mediator in several in vitro and in vivo studies, but its effect on allergic pulmonary inflammation remains elusive. The aim of this study was to investigate the therapeutic potential of 15d-PGJ(2) based on distinct murine models of allergic asthma triggered by either ovalbumin (OVA) or house dust mite extract (HDM). Characteristics of lung inflammation, airway hyper-reactivity (AHR), mucus exacerbation, and lung remodeling in sensitized A/J mice treated or not with 15d-PGJ(2) were assessed. 15d-PGJ(2) treatments were carried out systemically or topically given via subcutaneous injection or intranasal instillation, respectively. Analyses were carried out 24?h after the last allergen provocation. Irrespective of the route of administration, 15d-PGJ(2) significantly inhibited the peribronchial accumulation of eosinophils and neutrophils, subepithelial fibrosis and also mucus exacerbation caused by either OVA or HDM challenge. The protective effect of 15d-PGJ(2) occurred in parallel with inhibition of allergen-induced AHR and lung tissue production of pro-inflammatory cytokines, such as interleukin (IL)-5, IL-13, IL-17, and TNF-?. Finally, 15d-PGJ(2) was found effective in inhibiting NF-?B phosphorylation upon HDM challenge as measured by Western blotting. In conclusion, our findings suggest that 15d-PGJ(2) can reduce crucial features of asthma, including AHR, lung inflammation, and remodeling in distinct murine models of the disease. These effects are associated with a decrease in lung tissue generation of pro-inflammatory cytokines by a mechanism related to downregulation of NF-?B phosphorylation. ä15-Deoxy-Delta-12,14-Prostaglandin J(2) Inhibits Lung Inflammation and(epmc).pdf DeepDyve Pubget Overpricing