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2017 ; 8
(ä): 1111
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The Burden of Binge and Heavy Drinking on the Brain: Effects on Adolescent and
Young Adult Neural Structure and Function
#MMPMID28713313
Cservenka A
; Brumback T
Front Psychol
2017[]; 8
(ä): 1111
PMID28713313
show ga
Introduction: Adolescence and young adulthood are periods of continued biological
and psychosocial maturation. Thus, there may be deleterious effects of consuming
large quantities of alcohol on neural development and associated cognition during
this time. The purpose of this mini review is to highlight neuroimaging research
that has specifically examined the effects of binge and heavy drinking on
adolescent and young adult brain structure and function. Methods: We review
cross-sectional and longitudinal studies of young binge and heavy drinkers that
have examined brain structure (e.g., gray and white matter volume, cortical
thickness, white matter microstructure) and investigated brain response using
functional magnetic resonance imaging (fMRI). Results: Binge and heavy-drinking
adolescents and young adults have systematically thinner and lower volume in
prefrontal cortex and cerebellar regions, and attenuated white matter
development. They also show elevated brain activity in fronto-parietal regions
during working memory, verbal learning, and inhibitory control tasks. In response
to alcohol cues, relative to controls or light-drinking individuals, binge and
heavy drinkers show increased neural response mainly in mesocorticolimbic
regions, including the striatum, anterior cingulate cortex (ACC), hippocampus,
and amygdala. Mixed findings are present in risky decision-making tasks, which
could be due to large variation in task design and analysis. Conclusions: These
findings suggest altered neural structure and activity in binge and
heavy-drinking youth may be related to the neurotoxic effects of consuming
alcohol in large quantities during a highly plastic neurodevelopmental period,
which could result in neural reorganization, and increased risk for developing an
alcohol use disorder (AUD).