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10.2169/internalmedicine.56.8084

http://scihub22266oqcxt.onion/10.2169/internalmedicine.56.8084
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C5491813!5491813!28502933
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suck abstract from ncbi


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pmid28502933      Intern+Med 2017 ; 56 (10): 1179-84
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  • Sustained Tubulointerstitial Inflammation in Kidney with Severe Leptospirosis #MMPMID28502933
  • Tanaka K; Tanabe K; Nishii N; Takiue K; Sugiyama H; Wada J
  • Intern Med 2017[May]; 56 (10): 1179-84 PMID28502933show ga
  • Leptospirosis is frequently associated with acute kidney injury. Some survivors are known to progress to chronic kidney disease due to sustained tubulointerstitial inflammation. We present a case of severe leptospirosis with acute renal failure. Although antibiotic therapy resolved the infection, moderate renal dysfunction remained. A renal biopsy demonstrated marked inflammatory infiltration in the tubules and interstitium. Many of the inflammatory cells were CD68-positive monocytes/macrophages, predominantly M1 phenotype. An intermediate dose of oral corticosteroids normalized the patient's serum creatinine levels. We suggest that corticosteroid therapy may be a therapeutic option for some patients with sustained tubulointerstitial nephritis who survive severe leptospirosis.
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