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10.1681/ASN.2016070729 http://scihub22266oqcxt.onion/10.1681/ASN.2016070729 C5491280!5491280!28193826     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28193826&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Soc+Nephrol 2017 ; 28 (7): 2038-52 Nephropedia Template TP {{tp|p=28193826|t=2017. The NLRP3 Inflammasome Has a Critical Role in Peritoneal Dialysis-Related Peritonitis |pdf=|usr=}}{{28193826}} gab.com Text The NLRP3 Inflammasome Has a Critical Role in Peritoneal Dialysis-Related Peritonitis JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28193826 #FOAvip Bacterial peritonitis remains the main cause of technique failure in peritoneal dialysis (PD). During peritonitis, the peritoneal membrane undergoes structural and functional alterations that are mediated by IL-1?. The NLRP3 inflammasome is a caspase-1?activating multiprotein complex that links sensing of microbial and stress products to activation of proinflammatory cytokines, including IL-1?. The potential roles of the NLRP3 inflammasome and IL-1? in the peritoneal membrane during acute peritonitis have not been investigated. Here, we show that the NLRP3 inflammasome is activated during acute bacterial peritonitis in patients on PD, and this activation associates with the release of IL-1? in the dialysate. In mice, lipopolysaccharide- or Escherichia coli-induced peritonitis led to IL-1? release in the peritoneal membrane. The genetic deletion of Nalp3, which encodes NLRP3, abrogated defects in solute transport during acute peritonitis and restored ultrafiltration. In human umbilical vein endothelial cells, IL-1? treatment directly enhanced endothelial cell proliferation and increased microvascular permeability. These in vitro effects require endothelial IL-1 receptors, shown by immunofluorescence to be expressed in peritoneal capillaries in mice. Furthermore, administration of the IL-1? receptor antagonist, anakinra, efficiently decreased nitric oxide production and vascular proliferation and restored peritoneal function in mouse models of peritonitis, even in mice treated with standard-of-care antibiotherapy. These data demonstrate that NLRP3 activation and IL-1? release have a critical role in solute transport defects and tissue remodeling during PD-related peritonitis. Blockade of the NLRP3/IL-1? axis offers a novel method for rescuing morphologic alterations and transport defects during acute peritonitis. Twit Text FOAVip The NLRP3 Inflammasome Has a Critical Role in Peritoneal Dialysis-Related Peritonitis ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=28193826 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28193826 #FOAvip English Wikipedia <ref>{{Cite pmid|28193826}}</ref> The NLRP3 Inflammasome Has a Critical Role in Peritoneal Dialysis-Related Peritonitis #MMPMID28193826 Hautem N; Morelle J; Sow A; Corbet C; Feron O; Goffin E; Huaux F; Devuyst O J Am Soc Nephrol 2017[Jul]; 28 (7): 2038-52 PMID28193826show ga Bacterial peritonitis remains the main cause of technique failure in peritoneal dialysis (PD). During peritonitis, the peritoneal membrane undergoes structural and functional alterations that are mediated by IL-1?. The NLRP3 inflammasome is a caspase-1?activating multiprotein complex that links sensing of microbial and stress products to activation of proinflammatory cytokines, including IL-1?. The potential roles of the NLRP3 inflammasome and IL-1? in the peritoneal membrane during acute peritonitis have not been investigated. Here, we show that the NLRP3 inflammasome is activated during acute bacterial peritonitis in patients on PD, and this activation associates with the release of IL-1? in the dialysate. In mice, lipopolysaccharide- or Escherichia coli-induced peritonitis led to IL-1? release in the peritoneal membrane. The genetic deletion of Nalp3, which encodes NLRP3, abrogated defects in solute transport during acute peritonitis and restored ultrafiltration. In human umbilical vein endothelial cells, IL-1? treatment directly enhanced endothelial cell proliferation and increased microvascular permeability. These in vitro effects require endothelial IL-1 receptors, shown by immunofluorescence to be expressed in peritoneal capillaries in mice. Furthermore, administration of the IL-1? receptor antagonist, anakinra, efficiently decreased nitric oxide production and vascular proliferation and restored peritoneal function in mouse models of peritonitis, even in mice treated with standard-of-care antibiotherapy. These data demonstrate that NLRP3 activation and IL-1? release have a critical role in solute transport defects and tissue remodeling during PD-related peritonitis. Blockade of the NLRP3/IL-1? axis offers a novel method for rescuing morphologic alterations and transport defects during acute peritonitis. äThe NLRP3 Inflammasome Has a Critical Role in Peritoneal Dialysis-Rela(epmc).pdf DeepDyve Pubget Overpricing