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2017 ; 36
(2
): 200-204
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Rapid deterioration of preexisting renal insufficiency after autologous
mesenchymal stem cell therapy
#MMPMID28680828
Kim JS
; Lee JH
; Kwon O
; Cho JH
; Choi JY
; Park SH
; Kim CD
; Kim YJ
; Kim YL
Kidney Res Clin Pract
2017[Jun]; 36
(2
): 200-204
PMID28680828
show ga
Administration of autologous mesenchymal stem cells (MSCs) has been shown to
improve renal function and histological findings in acute kidney injury (AKI)
models. However, its effects in chronic kidney disease (CKD) are unclear,
particularly in the clinical setting. Here, we report our experience with a CKD
patient who was treated by intravenous infusion of autologous MSCs derived from
adipose tissue in an unknown clinic outside of Korea. The renal function of the
patient had been stable for several years before MSC administration. One week
after the autologous MSC infusion, the preexisting renal insufficiency was
rapidly aggravated without any other evidence of AKI. Hemodialysis was started 3
months after MSC administration. Renal biopsy findings at dialysis showed severe
interstitial fibrosis and inflammatory cell infiltration, with a few cells
expressing CD34 and CD117, 2 surface markers of stem cells. This case highlights
the potential nephrotoxicity of autologous MSC therapy in CKD patients.