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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Kidney+Res+Clin+Pract
2017 ; 36
(2
): 132-144
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A unified pathogenesis for kidney diseases, including genetic diseases and
cancers, by the protein-homeostasis-system hypothesis
#MMPMID28680821
Lee KY
Kidney Res Clin Pract
2017[Jun]; 36
(2
): 132-144
PMID28680821
show ga
Every cell of an organism is separated and protected by a cell membrane. It is
proposed that harmony between intercellular communication and the health of an
organism is controlled by a system, designated the protein-homeostasis-system
(PHS). Kidneys consist of a variety of types of renal cells, each with its own
characteristic cell-receptor interactions and producing characteristic proteins.
A functional union of these renal cells can be determined by various renal
function tests, and harmonious intercellular communication is essential for the
healthy state of the host. Injury to a kind of renal cells can impair renal
function and induce an imbalance in total body health. Every acute or chronic
renal disease has unknown etiologic substances that are responsible for renal
cell injury at the molecular level. The immune/repair system of the host should
control the etiologic substances acting against renal cells; if this system
fails, the disease progresses to end stage renal disease. Each renal disease has
its characteristic pathologic lesions where immune cells and immune proteins,
such as immunoglobulins and complements, are infiltrated. These immune cells and
immune proteins may control the etiologic substances involved in renal pathologic
lesions. Also, genetic renal diseases and cancers may originate from a protein
deficiency or malfunctioning protein under the PHS. A unified pathogenesis for
renal diseases, including acute glomerulonephritis, idiopathic nephrotic
syndrome, immunoglobulin A nephropathy, genetic renal diseases such as Alport
syndrome, and malignancies such as Wilms tumor and renal cell carcinoma, is
proposed using the PHS hypothesis.
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