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10.1371/journal.pone.0180083 http://scihub22266oqcxt.onion/10.1371/journal.pone.0180083 C5491127!5491127!28662096     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2017 ; 12 (6): ä Nephropedia Template TP {{tp|p=28662096|t=2017. Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations |pdf=|usr=}}{{28662096}} gab.com Text Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28662096 #FOAvip Ultrasensitive response motifs, capable of converting graded stimuli into binary responses, are well-conserved in signal transduction networks. Although it has been shown that a cascade arrangement of multiple ultrasensitive modules can enhance the system?s ultrasensitivity, how a given combination of layers affects a cascade?s ultrasensitivity remains an open question for the general case. Here, we introduce a methodology that allows us to determine the presence of sequestration effects and to quantify the relative contribution of each module to the overall cascade?s ultrasensitivity. The proposed analysis framework provides a natural link between global and local ultrasensitivity descriptors and it is particularly well-suited to characterize and understand mathematical models used to study real biological systems. As a case study, we have considered three mathematical models introduced by O?Shaughnessy et al. to study a tunable synthetic MAPK cascade, and we show how our methodology can help modelers better understand alternative models. Twit Text FOAVip Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28662096 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28662096 #FOAvip English Wikipedia <ref>{{Cite pmid|28662096}}</ref> Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations #MMPMID28662096 Altszyler E; Ventura AC; Colman-Lerner A; Chernomoretz A PLoS One 2017[]; 12 (6): ä PMID28662096show ga Ultrasensitive response motifs, capable of converting graded stimuli into binary responses, are well-conserved in signal transduction networks. Although it has been shown that a cascade arrangement of multiple ultrasensitive modules can enhance the system?s ultrasensitivity, how a given combination of layers affects a cascade?s ultrasensitivity remains an open question for the general case. Here, we introduce a methodology that allows us to determine the presence of sequestration effects and to quantify the relative contribution of each module to the overall cascade?s ultrasensitivity. The proposed analysis framework provides a natural link between global and local ultrasensitivity descriptors and it is particularly well-suited to characterize and understand mathematical models used to study real biological systems. As a case study, we have considered three mathematical models introduced by O?Shaughnessy et al. to study a tunable synthetic MAPK cascade, and we show how our methodology can help modelers better understand alternative models. äUltrasensitivity in signaling cascades revisited: Linking local and gl(epmc).pdf DeepDyve Pubget Overpricing