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10.1038/ni.3631 http://scihub22266oqcxt.onion/10.1038/ni.3631 C5490839!5490839 !27869819     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27869819 &cmd=llinks): Failed to open stream: HTTP request failed! 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A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli |pdf=|usr=}}{{27869819 }} gab.com Text A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27869819 #FOAvip Cell-surface-receptor pathways amplify weak, rare and local stimuli to induce cellular responses. This task is accomplished despite signaling components that segregate into nanometer-scale membrane domains. Here we describe a 'catch-and-release' mechanism that amplified and dispersed stimuli by releasing activated kinases from receptors lacking intrinsic catalytic activity. Specifically, we discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T cell antigen receptors (TCRs). This turned the TCR into a 'catalytic unit' that amplified antigenic stimuli. Zap70 released from the TCR remained at the membrane, translocated, and phosphorylated spatially distinct substrates. The mechanisms described here are based on widely used protein domains and post-translational modifications; therefore, many membrane-associated pathways might employ similar mechanisms for signal amplification and dispersion. Twit Text FOAVip A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27869819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27869819 #FOAvip English Wikipedia <ref>{{Cite pmid|27869819 }}</ref> A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli #MMPMID27869819 Katz ZB ; Novotná L ; Blount A ; Lillemeier BF Nat Immunol 2017[Jan]; 18 (1 ): 86-95 PMID27869819 show ga Cell-surface-receptor pathways amplify weak, rare and local stimuli to induce cellular responses. This task is accomplished despite signaling components that segregate into nanometer-scale membrane domains. Here we describe a 'catch-and-release' mechanism that amplified and dispersed stimuli by releasing activated kinases from receptors lacking intrinsic catalytic activity. Specifically, we discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T cell antigen receptors (TCRs). This turned the TCR into a 'catalytic unit' that amplified antigenic stimuli. Zap70 released from the TCR remained at the membrane, translocated, and phosphorylated spatially distinct substrates. The mechanisms described here are based on widely used protein domains and post-translational modifications; therefore, many membrane-associated pathways might employ similar mechanisms for signal amplification and dispersion. |*Activity Cycles [MESH] |Adaptor Proteins, Signal Transducing/metabolism [MESH] |Animals [MESH] |Antigens/immunology [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Jurkat Cells [MESH] |Lymphocyte Activation [MESH] |Membrane Proteins/metabolism [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Phosphoproteins/metabolism [MESH] |Receptor Cross-Talk [MESH] |Receptors, Antigen, T-Cell/genetics/*metabolism [MESH] |Signal Transduction/*immunology [MESH] |T-Lymphocytes/*immunology [MESH]A cycle of Zap70 kinase activation and release from the TCR amplifies (epmc).pdf DeepDyve Pubget Overpricing