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10.3390/v9060131 http://scihub22266oqcxt.onion/10.3390/v9060131 C5490808!5490808!28561751     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2017 ; 9 (6): ä Nephropedia Template TP {{tp|p=28561751|t=2017. The Role of Somatic L1 Retrotransposition in Human Cancers |pdf=|usr=}}{{28561751}} gab.com Text The Role of Somatic L1 Retrotransposition in Human Cancers JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=28561751 #FOAvip The human LINE-1 (or L1) element is a non-LTR retrotransposon that is mobilized through an RNA intermediate by an L1-encoded reverse transcriptase and other L1-encoded proteins. L1 elements remain actively mobile today and continue to mutagenize human genomes. Importantly, when new insertions disrupt gene function, they can cause diseases. Historically, L1s were thought to be active in the germline but silenced in adult somatic tissues. However, recent studies now show that L1 is active in at least some somatic tissues, including epithelial cancers. In this review, we provide an overview of these recent developments, and examine evidence that somatic L1 retrotransposition can initiate and drive tumorigenesis in humans. Recent studies have: (i) cataloged somatic L1 activity in many epithelial tumor types; (ii) identified specific full-length L1 source elements that give rise to somatic L1 insertions; and (iii) determined that L1 promoter hypomethylation likely plays an early role in the derepression of L1s in somatic tissues. A central challenge moving forward is to determine the extent to which L1 driver mutations can promote tumor initiation, evolution, and metastasis in humans. Twit Text FOAVip The Role of Somatic L1 Retrotransposition in Human Cancers ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=28561751 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28561751 #FOAvip English Wikipedia <ref>{{Cite pmid|28561751}}</ref> The Role of Somatic L1 Retrotransposition in Human Cancers #MMPMID28561751 Scott EC; Devine SE Viruses 2017[Jun]; 9 (6): ä PMID28561751show ga The human LINE-1 (or L1) element is a non-LTR retrotransposon that is mobilized through an RNA intermediate by an L1-encoded reverse transcriptase and other L1-encoded proteins. L1 elements remain actively mobile today and continue to mutagenize human genomes. Importantly, when new insertions disrupt gene function, they can cause diseases. Historically, L1s were thought to be active in the germline but silenced in adult somatic tissues. However, recent studies now show that L1 is active in at least some somatic tissues, including epithelial cancers. In this review, we provide an overview of these recent developments, and examine evidence that somatic L1 retrotransposition can initiate and drive tumorigenesis in humans. Recent studies have: (i) cataloged somatic L1 activity in many epithelial tumor types; (ii) identified specific full-length L1 source elements that give rise to somatic L1 insertions; and (iii) determined that L1 promoter hypomethylation likely plays an early role in the derepression of L1s in somatic tissues. A central challenge moving forward is to determine the extent to which L1 driver mutations can promote tumor initiation, evolution, and metastasis in humans. äThe Role of Somatic L1 Retrotransposition in Human Cancers (epmc).pdf DeepDyve Pubget Overpricing