Wnt/PCP Instructions for Cilia in Left-Right Asymmetry #MMPMID28292419
Wu J; Mlodzik M
Dev Cell 2017[Mar]; 40 (5): 423-4 PMID28292419show ga
Wnt-Frizzled/planar cell polarity (PCP) signaling establishes cell orientation within the epithelial plane, but whether Wnts are instructive or permissive is debated. Reporting in Developmental Cell, Minegishi et al. (2017) uncover an instructive link from Wnt5a/b gradients to PCP-factor-regulated polarized cilia positioning that is essential to mouse embryo left-right asymmetry establishment.