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10.1172/JCI89607 http://scihub22266oqcxt.onion/10.1172/JCI89607 C5490778!5490778!28530642     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest ä ; 127 (7): 2569-85 Nephropedia Template TP {{tp|p=28530642|t=ä. RASA1 regulates the function of lymphatic vessel valves in mice |pdf=|usr=}}{{28530642}} gab.com Text RASA1 regulates the function of lymphatic vessel valves in mice JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28530642 #FOAvip Capillary malformation?arteriovenous malformation (CM-AVM) is a blood and lymphatic vessel (LV) disorder that is caused by inherited inactivating mutations of the RASA1 gene, which encodes p120 RasGAP (RASA1), a negative regulator of the Ras small GTP-binding protein. How RASA1 mutations lead to the LV leakage defects that occur in CM-AVM is not understood. Here, we report that disruption of the Rasa1 gene in adult mice resulted in loss of LV endothelial cells (LECs) specifically from the leaflets of intraluminal valves in collecting LVs. As a result, valves were unable to prevent fluid backflow and the vessels were ineffective pumps. Furthermore, disruption of Rasa1 in midgestation resulted in LEC apoptosis in developing LV valves and consequently failed LV valvulogenesis. Similar phenotypes were observed in induced RASA1-deficient adult mice and embryos expressing a catalytically inactive RASA1R780Q mutation. Thus, RASA1 catalytic activity is essential for the function and development of LV valves. These data provide a partial explanation for LV leakage defects and potentially other LV abnormalities observed in CM-AVM. Twit Text FOAVip RASA1 regulates the function of lymphatic vessel valves in mice ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=28530642 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28530642 #FOAvip English Wikipedia <ref>{{Cite pmid|28530642}}</ref> RASA1 regulates the function of lymphatic vessel valves in mice #MMPMID28530642 Lapinski PE; Lubeck BA; Chen D; Doosti A; Zawieja SD; Davis MJ; King PD J Clin Invest ä[]; 127 (7): 2569-85 PMID28530642show ga Capillary malformation?arteriovenous malformation (CM-AVM) is a blood and lymphatic vessel (LV) disorder that is caused by inherited inactivating mutations of the RASA1 gene, which encodes p120 RasGAP (RASA1), a negative regulator of the Ras small GTP-binding protein. How RASA1 mutations lead to the LV leakage defects that occur in CM-AVM is not understood. Here, we report that disruption of the Rasa1 gene in adult mice resulted in loss of LV endothelial cells (LECs) specifically from the leaflets of intraluminal valves in collecting LVs. As a result, valves were unable to prevent fluid backflow and the vessels were ineffective pumps. Furthermore, disruption of Rasa1 in midgestation resulted in LEC apoptosis in developing LV valves and consequently failed LV valvulogenesis. Similar phenotypes were observed in induced RASA1-deficient adult mice and embryos expressing a catalytically inactive RASA1R780Q mutation. Thus, RASA1 catalytic activity is essential for the function and development of LV valves. These data provide a partial explanation for LV leakage defects and potentially other LV abnormalities observed in CM-AVM. äRASA1 regulates the function of lymphatic vessel valves in mice (epmc).pdf DeepDyve Pubget Overpricing