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10.1038/ncomms15839 http://scihub22266oqcxt.onion/10.1038/ncomms15839 C5490010!5490010 !28643776     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28643776 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 15839 Nephropedia Template TP {{tp|p=28643776 |t=2017. Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation |pdf=|usr=}}{{28643776 }} gab.com Text Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28643776 #FOAvip Transendothelial cell macroaperture (TEM) tunnels control endothelium barrier function and are triggered by several toxins from pathogenic bacteria that provoke vascular leakage. Cellular dewetting theory predicted that a line tension of uncharacterized origin works at TEM boundaries to limit their widening. Here, by conducting high-resolution microscopy approaches we unveil the presence of an actomyosin cable encircling TEMs. We develop a theoretical cellular dewetting framework to interpret TEM physical parameters that are quantitatively determined by laser ablation experiments. This establishes the critical role of ezrin and non-muscle myosin II (NMII) in the progressive implementation of line tension. Mechanistically, fluorescence-recovery-after-photobleaching experiments point for the upstream role of ezrin in stabilizing actin filaments at the edges of TEMs, thereby favouring their crosslinking by NMIIa. Collectively, our findings ascribe to ezrin and NMIIa a critical function of enhancing line tension at the cell boundary surrounding the TEMs by promoting the formation of an actomyosin ring. Twit Text FOAVip Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28643776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28643776 #FOAvip English Wikipedia <ref>{{Cite pmid|28643776 }}</ref> Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation #MMPMID28643776 Stefani C ; Gonzalez-Rodriguez D ; Senju Y ; Doye A ; Efimova N ; Janel S ; Lipuma J ; Tsai MC ; Hamaoui D ; Maddugoda MP ; Cochet-Escartin O ; Prévost C ; Lafont F ; Svitkina T ; Lappalainen P ; Bassereau P ; Lemichez E Nat Commun 2017[Jun]; 8 (ä): 15839 PMID28643776 show ga Transendothelial cell macroaperture (TEM) tunnels control endothelium barrier function and are triggered by several toxins from pathogenic bacteria that provoke vascular leakage. Cellular dewetting theory predicted that a line tension of uncharacterized origin works at TEM boundaries to limit their widening. Here, by conducting high-resolution microscopy approaches we unveil the presence of an actomyosin cable encircling TEMs. We develop a theoretical cellular dewetting framework to interpret TEM physical parameters that are quantitatively determined by laser ablation experiments. This establishes the critical role of ezrin and non-muscle myosin II (NMII) in the progressive implementation of line tension. Mechanistically, fluorescence-recovery-after-photobleaching experiments point for the upstream role of ezrin in stabilizing actin filaments at the edges of TEMs, thereby favouring their crosslinking by NMIIa. Collectively, our findings ascribe to ezrin and NMIIa a critical function of enhancing line tension at the cell boundary surrounding the TEMs by promoting the formation of an actomyosin ring. |Actin Cytoskeleton/chemistry/genetics/metabolism [MESH] |Actomyosin/chemistry/genetics/*metabolism [MESH] |Cytoskeletal Proteins/chemistry/genetics/*metabolism [MESH] |Human Umbilical Vein Endothelial Cells/chemistry/metabolism [MESH] |Humans [MESH] |Nonmuscle Myosin Type IIA/chemistry/genetics/*metabolism [MESH]Ezrin enhances line tension along transcellular tunnel edges via NMIIa(epmc).pdf DeepDyve Pubget Overpricing