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10.1038/ncomms15936 http://scihub22266oqcxt.onion/10.1038/ncomms15936 C5490007!5490007!28643781     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28643781&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28643781.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28643781|t=2017. Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma |pdf=|usr=}}{{28643781}} gab.com Text Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28643781 #FOAvip Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date, comprising 112 childhood and adult tumours encompassing all major histological subtypes. A key finding of our study is the identification of mutations in insulin-like growth factor (IGF) signalling genes in 8/112 (7%) of cases. We validate this observation using fluorescence in situ hybridization (FISH) in an additional 87 osteosarcomas, with IGF1 receptor (IGF1R) amplification observed in 14% of tumours. These findings may inform patient selection in future trials of IGF1R inhibitors in osteosarcoma. Analysing patterns of mutation, we identify distinct rearrangement profiles including a process characterized by chromothripsis and amplification. This process operates recurrently at discrete genomic regions and generates driver mutations. It may represent an age-independent mutational mechanism that contributes to the development of osteosarcoma in children and adults alike. Twit Text FOAVip Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28643781 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28643781 #FOAvip English Wikipedia <ref>{{Cite pmid|28643781}}</ref> Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma #MMPMID28643781 Behjati S; Tarpey PS; Haase K; Ye H; Young MD; Alexandrov LB; Farndon SJ; Collord G; Wedge DC; Martincorena I; Cooke SL; Davies H; Mifsud W; Lidgren M; Martin S; Latimer C; Maddison M; Butler AP; Teague JW; Pillay N; Shlien A; McDermott U; Futreal PA; Baumhoer D; Zaikova O; Bjerkehagen B; Myklebost O; Amary MF; Tirabosco R; Van Loo P; Stratton MR; Flanagan AM; Campbell PJ Nat Commun 2017[]; 8 (ä): ä PMID28643781show ga Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date, comprising 112 childhood and adult tumours encompassing all major histological subtypes. A key finding of our study is the identification of mutations in insulin-like growth factor (IGF) signalling genes in 8/112 (7%) of cases. We validate this observation using fluorescence in situ hybridization (FISH) in an additional 87 osteosarcomas, with IGF1 receptor (IGF1R) amplification observed in 14% of tumours. These findings may inform patient selection in future trials of IGF1R inhibitors in osteosarcoma. Analysing patterns of mutation, we identify distinct rearrangement profiles including a process characterized by chromothripsis and amplification. This process operates recurrently at discrete genomic regions and generates driver mutations. It may represent an age-independent mutational mechanism that contributes to the development of osteosarcoma in children and adults alike. äRecurrent mutation of IGF signalling genes and distinct patterns of ge(epmc).pdf DeepDyve Pubget Overpricing