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10.1177/2168479013513889

http://scihub22266oqcxt.onion/10.1177/2168479013513889
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C5489916!5489916!28670507
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suck abstract from ncbi


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pmid28670507      Ther+Innov+Regul+Sci 2014 ; 48 (1): 20-30
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  • Adaptive Clinical Trials: Overview of Early-Phase Designs and Challenges #MMPMID28670507
  • Marchenko O; Fedorov V; Lee JJ; Nolan C; Pinheiro J
  • Ther Innov Regul Sci 2014[Jan]; 48 (1): 20-30 PMID28670507show ga
  • In this paper, we describe developments in adaptive design methodology and discuss implementation strategies and operational challenges in early phase adaptive clinical trials. The BATTLE trial ? the first completed, biomarker-based, Bayesian adaptive randomized study in lung cancer ? is presented as a case study to illustrate main ideas and share learnings.
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