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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Transl+Res
2017 ; 9
(6
): 2807-2823
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Circulating tumor cells: what we know, what do we want to know about them and are
they ready to be used in clinics?
#MMPMID28670371
Biel?iková Z
; Jakabová A
; Pinkas M
; Zemanová M
; Kolo?tová K
; Bobek V
Am J Transl Res
2017[]; 9
(6
): 2807-2823
PMID28670371
show ga
Circulating tumor cells (CTC) present in peripheral blood are assigned precursors
of advanced tumor disease. Simplicity of blood withdrawal procedure adds
practically an unlimited possibility of the CTC-monitoring and the advantages of
the repeated biopsies over time. CTC got prognostic, predictive and diagnostic
status with the technologic advance. Although the clinical utility of CTC has
reached the high evidence, the significance of CTC testing was presented in the
treatment strategy mostly with palliative intention. We report on the experiences
with the CTC-testing in the CLIA-like laboratory working with the size-based CTC
separation and in vitro culture. The data is presented in the form of case
reports in patients with breast (BC), colorectal (CRC), prostate (PC) and lung
cancer (NSCLC) to support the clinical utility of CTC during the neoadjuvant,
adjuvant and palliative treatment. The presented findings support the evidence
for liquid biopsy clinical implementation and enhance the ability of malignant
disease monitoring and the treatment efficacy prediction.