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10.3390/biomedicines5020034 http://scihub22266oqcxt.onion/10.3390/biomedicines5020034 C5489820!5489820!28635679     free     free     free       Biomedicines 2017 ; 5 (2): ä Nephropedia Template TP {{tp|p=28635679|t=2017. The Role of Angiogenesis in Cancer Treatment |pdf=|usr=}}{{28635679}} gab.com Text The Role of Angiogenesis in Cancer Treatment JO: Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=28635679 #FOAvip A number of anti-angiogenesis drugs have been FDA-approved and are being used in cancer treatment, and a number of other agents are in different stages of clinical development or in preclinical evaluation. However, pharmacologic anti-angiogenesis strategies that arrest tumor progression might not be enough to eradicate tumors. Decreased anti-angiogenesis activity in single mechanism-based anti-angiogenic strategies is due to the redundancy, multiplicity, and development of compensatory mechanism by which blood vessels are remodeled. Improving anti-angiogenesis drug efficacy will require identification of broad-spectrum anti-angiogenesis targets. These strategies may have novel features, such as increased porosity, and are the result of complex interactions among endothelial cells, extracellular matrix proteins, growth factors, pericyte, and smooth muscle cells. Thus, combinations of anti-angiogenic drugs and other anticancer strategies such as chemotherapy appear essential for optimal outcome in cancer patients. This review will focus on the role of anti-angiogenesis strategies in cancer treatment. Twit Text FOAVip The Role of Angiogenesis in Cancer Treatment ????Biomedicines http://www.kidney.de/pget.php?&tw=1&pmid=28635679 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28635679 #FOAvip English Wikipedia <ref>{{Cite pmid|28635679}}</ref> The Role of Angiogenesis in Cancer Treatment #MMPMID28635679 Rajabi M; Mousa SA Biomedicines 2017[Jun]; 5 (2): ä PMID28635679show ga A number of anti-angiogenesis drugs have been FDA-approved and are being used in cancer treatment, and a number of other agents are in different stages of clinical development or in preclinical evaluation. However, pharmacologic anti-angiogenesis strategies that arrest tumor progression might not be enough to eradicate tumors. Decreased anti-angiogenesis activity in single mechanism-based anti-angiogenic strategies is due to the redundancy, multiplicity, and development of compensatory mechanism by which blood vessels are remodeled. Improving anti-angiogenesis drug efficacy will require identification of broad-spectrum anti-angiogenesis targets. These strategies may have novel features, such as increased porosity, and are the result of complex interactions among endothelial cells, extracellular matrix proteins, growth factors, pericyte, and smooth muscle cells. Thus, combinations of anti-angiogenic drugs and other anticancer strategies such as chemotherapy appear essential for optimal outcome in cancer patients. This review will focus on the role of anti-angiogenesis strategies in cancer treatment. äThe Role of Angiogenesis in Cancer Treatment (epmc).pdf DeepDyve Pubget Overpricing