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2017 ; 7
(6
): 1372-1383
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gab.com Text
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English Wikipedia
Mucins in pancreatic cancer: biological role, implications in carcinogenesis and
applications in diagnosis and therapy
#MMPMID28670497
Suh H
; Pillai K
; Morris DL
Am J Cancer Res
2017[]; 7
(6
): 1372-1383
PMID28670497
show ga
Pancreatic cancer is the fourth highest cause of cancer mortality in the world.
It has very low survival rates owing to late diagnosis resulting from the absence
of accurate diagnostic tools and effective therapies. Hence, there is a pressing
need to develop new diagnostic and therapeutic tools. In the recent years, there
has been new evidence implicating the importance of mucins in pancreatic
carcinogenesis. Mucins belong to a group of heavily glycosylated proteins, and
are often aberrantly expressed in a number of cancers such as pancreatic cancer.
Therefore, this literature review will summarise the role of mucins and mucin
expression in pancreatic neoplasms. Subsequently the paper will also discuss the
most recent advances in the biological properties of mucins and their role in
carcinogenesis and resistance to chemotherapy. Then it will conclude on the
newest developments in diagnosis and therapy based on mucins for pancreatic
cancer.