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2017 ; 37
(5
): 461-475
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gab.com Text
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English Wikipedia
Health-Related Quality of Life in Adult Patients with Common Variable
Immunodeficiency Disorders and Impact of Treatment
#MMPMID28536745
Rider NL
; Kutac C
; Hajjar J
; Scalchunes C
; Seeborg FO
; Boyle M
; Orange JS
J Clin Immunol
2017[Jul]; 37
(5
): 461-475
PMID28536745
show ga
PURPOSE: Common variable immunodeficiency disorder (CVID) is a primary
immunodeficiency disease (PIDD) often associated with severe and chronic
infections. Patients commonly receive immunoglobulin (Ig) treatment to reduce the
cycle of recurrent infection and improve physical functioning. However, how Ig
treatment in CVID affects quality of life (QOL) has not been thoroughly
evaluated. The purpose of a recent Immune Deficiency Foundation (IDF) mail survey
was to assess the factors that are associated with QOL in patients with CVID
receiving Ig treatment. METHODS: A 75-question survey developed by the IDF and a
12-item Short Form Health Survey (SF-12) to assess QOL were mailed to adults with
CVID. Mean SF-12 scores were compared between patients with CVID and the general
US adult population normative sample. RESULTS: Overall, 945 patients with CVID
completed the surveys. More than half of the patients (54.9%) received
intravenous Ig and 44.9% received subcutaneous Ig treatment. Patients with CVID
had significantly lower SF-12 scores compared with the general US population
regardless of sex or age (p < 0.05). Route of IgG replacement did not
dramatically improve QOL. SF-12 scores were highest in patients with CVID who
have well-controlled PIDD, lacked physical impairments, were not bothered by
treatment, and received Ig infusions at home. CONCLUSION: These data provide
insight into what factors are most associated with physical and mental health,
which can serve to improve QOL in patients in this population. Improvements in
QOL can result from early detection of disease, limiting digestive system
disease, attention to fatigue, and implementation of an individual treatment plan
for the patient.