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10.1371/journal.pone.0179100 http://scihub22266oqcxt.onion/10.1371/journal.pone.0179100 C5489165!5489165!28658263     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2017 ; 12 (6): ä Nephropedia Template TP {{tp|p=28658263|t=2017. Identification of benzazole compounds that induce HIV-1 transcription |pdf=|usr=}}{{28658263}} gab.com Text Identification of benzazole compounds that induce HIV-1 transcription JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28658263 #FOAvip Despite advances in antiretroviral therapy, HIV-1 infection remains incurable in patients and continues to present a significant public health burden worldwide. While a number of factors contribute to persistent HIV-1 infection in patients, the presence of a stable, long-lived reservoir of latent provirus represents a significant hurdle in realizing an effective cure. One potential strategy to eliminate HIV-1 reservoirs in patients is reactivation of latent provirus with latency reversing agents in combination with antiretroviral therapy, a strategy termed ?shock and kill?. This strategy has shown limited clinical effectiveness thus far, potentially due to limitations of the few therapeutics currently available. We have identified a novel class of benzazole compounds effective at inducing HIV-1 expression in several cellular models. These compounds do not act via histone deacetylase inhibition or T cell activation, and show specificity in activating HIV-1 in vitro. Initial exploration of structure-activity relationships and pharmaceutical properties indicates that these compounds represent a potential scaffold for development of more potent HIV-1 latency reversing agents. Twit Text FOAVip Identification of benzazole compounds that induce HIV-1 transcription ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28658263 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28658263 #FOAvip English Wikipedia <ref>{{Cite pmid|28658263}}</ref> Identification of benzazole compounds that induce HIV-1 transcription #MMPMID28658263 Graci JD; Michaels D; Chen G; Schiralli Lester GM; Nodder S; Weetall M; Karp GM; Gu Z; Colacino JM; Henderson AJ PLoS One 2017[]; 12 (6): ä PMID28658263show ga Despite advances in antiretroviral therapy, HIV-1 infection remains incurable in patients and continues to present a significant public health burden worldwide. While a number of factors contribute to persistent HIV-1 infection in patients, the presence of a stable, long-lived reservoir of latent provirus represents a significant hurdle in realizing an effective cure. One potential strategy to eliminate HIV-1 reservoirs in patients is reactivation of latent provirus with latency reversing agents in combination with antiretroviral therapy, a strategy termed ?shock and kill?. This strategy has shown limited clinical effectiveness thus far, potentially due to limitations of the few therapeutics currently available. We have identified a novel class of benzazole compounds effective at inducing HIV-1 expression in several cellular models. These compounds do not act via histone deacetylase inhibition or T cell activation, and show specificity in activating HIV-1 in vitro. Initial exploration of structure-activity relationships and pharmaceutical properties indicates that these compounds represent a potential scaffold for development of more potent HIV-1 latency reversing agents. äIdentification of benzazole compounds that induce HIV-1 transcription (epmc).pdf DeepDyve Pubget Overpricing