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10.1039/c5sc00524h http://scihub22266oqcxt.onion/10.1039/c5sc00524h C5489047!5489047 !28706668     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28706668 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Chem+Sci 2015 ; 6 (5 ): 2802-2805 Nephropedia Template TP {{tp|p=28706668 |t=2015. Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues |pdf=|usr=}}{{28706668 }} gab.com Text Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues JO: Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=28706668 #FOAvip Water-soluble bioadhesive polymers bearing multiple guanidinium ion (Gu(+)) pendants at their side-chain termini (Glue (n) -BA, n = 10 and 29) that were conjugated with benzamidine (BA) as a trypsin inhibitor were developed. The Glue (n) -BA molecules are supposed to adhere to oxyanionic regions of the trypsin surface, even in buffer, via a multivalent Gu(+)/oxyanion salt-bridge interaction, such that their BA group properly blocks the substrate-binding site. In fact, Glue(10)-BA and Glue(29)-BA exhibited 35- and 200-fold higher affinities for trypsin, respectively, than a BA derivative without the glue moiety (TEG-BA). Most importantly, Glue(10)-BA inhibited the protease activity of trypsin 13-fold more than TEG-BA. In sharp contrast, (m) Glue(27)-BA, which bears 27 Gu(+) units along the main chain and has a 5-fold higher affinity than TEG-BA for trypsin, was inferior even to TEG-BA for trypsin inhibition. Twit Text FOAVip Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues ????Chem Sci http://www.kidney.de/pget.php?&tw=1&pmid=28706668 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28706668 #FOAvip English Wikipedia <ref>{{Cite pmid|28706668 }}</ref> Molecular glues for manipulating enzymes: trypsin inhibition by benzamidine-conjugated molecular glues #MMPMID28706668 Mogaki R ; Okuro K ; Aida T Chem Sci 2015[May]; 6 (5 ): 2802-2805 PMID28706668 show ga Water-soluble bioadhesive polymers bearing multiple guanidinium ion (Gu(+)) pendants at their side-chain termini (Glue (n) -BA, n = 10 and 29) that were conjugated with benzamidine (BA) as a trypsin inhibitor were developed. The Glue (n) -BA molecules are supposed to adhere to oxyanionic regions of the trypsin surface, even in buffer, via a multivalent Gu(+)/oxyanion salt-bridge interaction, such that their BA group properly blocks the substrate-binding site. In fact, Glue(10)-BA and Glue(29)-BA exhibited 35- and 200-fold higher affinities for trypsin, respectively, than a BA derivative without the glue moiety (TEG-BA). Most importantly, Glue(10)-BA inhibited the protease activity of trypsin 13-fold more than TEG-BA. In sharp contrast, (m) Glue(27)-BA, which bears 27 Gu(+) units along the main chain and has a 5-fold higher affinity than TEG-BA for trypsin, was inferior even to TEG-BA for trypsin inhibition. äMolecular glues for manipulating enzymes: trypsin inhibition by benz(epmc).pdf DeepDyve Pubget Overpricing