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10.21873/anticanres.11492 http://scihub22266oqcxt.onion/10.21873/anticanres.11492 C5488875!5488875!28373422     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Anticancer+Res 2017 ; 37 (4): 1617-23 Nephropedia Template TP {{tp|p=28373422|t=2017. Differential Effect of Wortmannolone Derivatives on MDA-MB-231 Breast Cancer Cells |pdf=|usr=}}{{28373422}} gab.com Text Differential Effect of Wortmannolone Derivatives on MDA-MB-231 Breast Cancer Cells JO: Anticancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28373422 #FOAvip Background/Aim: The survival rate of women diagnosed with triple-negative breast-cancer (TNBC) remains low. Hence, this study aimed at the chemical and biological optimization of furanosteroid derivatives for the treatment of this type of malignancy using TNBC cells. Materials and Methods: Semi-synthetic analogs of wortmannolone (1?6) that negatively affected the aberrant pathways in tumor cells were evaluated in hormone-independent breast cancer cells using western blot and cell cycle analysis. Results: Wortmannolone derivatization generated NF-?B inhibitors as new lead structures for further development. Compound (3) was found to be the most significantly active lead. Conclusion: Structure-activity analysis in the present study showed that acetylation of the hydroxyl groups and substitution on C3 and C17 of wortmannolone enhanced biological activity. Alpha-substitution of the acetyl group in C3 on ring A (compound 3) resulted in ROS inducing effect; however, presence of an acetyl group in ?-position of C3 displayed the highest NF-?B p65 inhibitory activity (0.60 ?M). Twit Text FOAVip Differential Effect of Wortmannolone Derivatives on MDA-MB-231 Breast Cancer Cells ????Anticancer Res http://www.kidney.de/pget.php?&tw=1&pmid=28373422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28373422 #FOAvip English Wikipedia <ref>{{Cite pmid|28373422}}</ref> Differential Effect of Wortmannolone Derivatives on MDA-MB-231 Breast Cancer Cells #MMPMID28373422 ACUÑA UM; CURLEY RW; FATIMA N; AHMED S; CHANG LC; CARCACHE de BLANCO EJ Anticancer Res 2017[Apr]; 37 (4): 1617-23 PMID28373422show ga Background/Aim: The survival rate of women diagnosed with triple-negative breast-cancer (TNBC) remains low. Hence, this study aimed at the chemical and biological optimization of furanosteroid derivatives for the treatment of this type of malignancy using TNBC cells. Materials and Methods: Semi-synthetic analogs of wortmannolone (1?6) that negatively affected the aberrant pathways in tumor cells were evaluated in hormone-independent breast cancer cells using western blot and cell cycle analysis. Results: Wortmannolone derivatization generated NF-?B inhibitors as new lead structures for further development. Compound (3) was found to be the most significantly active lead. Conclusion: Structure-activity analysis in the present study showed that acetylation of the hydroxyl groups and substitution on C3 and C17 of wortmannolone enhanced biological activity. Alpha-substitution of the acetyl group in C3 on ring A (compound 3) resulted in ROS inducing effect; however, presence of an acetyl group in ?-position of C3 displayed the highest NF-?B p65 inhibitory activity (0.60 ?M). äDifferential Effect of Wortmannolone Derivatives on MDA-MB-231 Breast (epmc).pdf DeepDyve Pubget Overpricing