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10.1038/nature21690 http://scihub22266oqcxt.onion/10.1038/nature21690 C5488729!5488729!28297718     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2017 ; 543 (7646): 568-72 Nephropedia Template TP {{tp|p=28297718|t=2017. DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs |pdf=|usr=}}{{28297718}} gab.com Text DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=28297718 #FOAvip The vertebrate-conserved RNA-binding protein (RBP) DND1 is required for survival of primordial germ cells (PGCs), as well as germ cell tumour (TGCT) suppression in mice1?5. Here we report that DND1 binds a UU[A/U] trinucleotide motif predominantly in messenger RNA (mRNA) 3? untranslated regions (UTRs), and destabilizes target mRNAs through direct recruitment of the CCR4-NOT deadenylase (CCR4) complex. Transcriptomic analysis revealed that the extent of suppression is dependent on the number of DND1 binding sites. The DND1-dependent mRNA destabilization is required for survival of murine PGCs and spermatogonial stem cells (SSCs) by suppressing apoptosis. The target RNA spectrum includes positive regulators of apoptosis, inflammation, and modulators of signalling pathways regulating stem cell pluripotency including the TGF-? super family, all of which are aberrantly elevated in Dnd1-deficient PGCs. We propose that the induction of the posttranscriptional suppressor DND1 synergizes with concurrent transcriptional changes to sharpen developmental transitions during cellular differentiation and maintenance of the germline. Twit Text FOAVip DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=28297718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28297718 #FOAvip English Wikipedia <ref>{{Cite pmid|28297718}}</ref> DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs #MMPMID28297718 Yamaji M; Jishage M; Meyer C; Suryawanshi H; Der E; Yamaji M; Garzia A; Morozov P; Manickavel S; McFarland HL; Roeder RG; Hafner M; Tuschl T Nature 2017[Mar]; 543 (7646): 568-72 PMID28297718show ga The vertebrate-conserved RNA-binding protein (RBP) DND1 is required for survival of primordial germ cells (PGCs), as well as germ cell tumour (TGCT) suppression in mice1?5. Here we report that DND1 binds a UU[A/U] trinucleotide motif predominantly in messenger RNA (mRNA) 3? untranslated regions (UTRs), and destabilizes target mRNAs through direct recruitment of the CCR4-NOT deadenylase (CCR4) complex. Transcriptomic analysis revealed that the extent of suppression is dependent on the number of DND1 binding sites. The DND1-dependent mRNA destabilization is required for survival of murine PGCs and spermatogonial stem cells (SSCs) by suppressing apoptosis. The target RNA spectrum includes positive regulators of apoptosis, inflammation, and modulators of signalling pathways regulating stem cell pluripotency including the TGF-? super family, all of which are aberrantly elevated in Dnd1-deficient PGCs. We propose that the induction of the posttranscriptional suppressor DND1 synergizes with concurrent transcriptional changes to sharpen developmental transitions during cellular differentiation and maintenance of the germline. äDND1 maintains germline stem cells via recruitment of the CCR4-NOT com(epmc).pdf DeepDyve Pubget Overpricing