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10.1590/1678-4685-GMB-2016-0121

http://scihub22266oqcxt.onion/10.1590/1678-4685-GMB-2016-0121
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C5488467!5488467!28644508
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suck abstract from ncbi


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pmid28644508      Genet+Mol+Biol 2017 ; 40 (2): 525-9
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  • Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma #MMPMID28644508
  • Shi L; Zhang L; Wang C; Sun S; Cao X; Zhang X
  • Genet Mol Biol 2017[Apr]; 40 (2): 525-9 PMID28644508show ga
  • Studies have demonstrated that miRNA-378 is expressed in various malignant tumors. In the present study, we aimed to explore the expression of serum miRNA-378 and its clinical significance in renal cell carcinoma (RCC) patients. A total of 75 RCC patients, 63 renal cysts (RC) patients and 75 healthy controls were selected. The miRNA-378 level in RCC and RC groups was significantly higher than in healthy control group, with RCC group having the highest level. The miRNA-378 levels were significantly decreased within the same group after surgery. When compared with healthy controls, RC group had higher levels but not significantly (p > 0.05) while levels in RCC group were significantly higher (p < 0.05). miRNA-378 expression was correlated with clinical stage and differentiation degree, but not correlated with patient's age, gender, surgical strategy and tumor diameter. The AUC of miRNA-378 was 0.896, 95% confidence interval was 0.847 to 0.945, and AUC hypothesis testing was statistically significant (p < 0.001, RCC vs healthy control). miRNA-378 shows potential in the diagnosis and prediction of postoperative curative effect of renal cell carcinoma, but further studies with lager samples are needed.
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