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10.3892/etm.2017.4573 http://scihub22266oqcxt.onion/10.3892/etm.2017.4573 C5488411!5488411!28672967     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28672967&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Ther+Med 2017 ; 14 (1): 561-6 Nephropedia Template TP {{tp|p=28672967|t=2017. Artesunate ameliorates lung fibrosis via inhibiting the Notch signaling pathway |pdf=|usr=}}{{28672967}} gab.com Text Artesunate ameliorates lung fibrosis via inhibiting the Notch signaling pathway JO: Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=28672967 #FOAvip The present study aimed to determine the underlying molecular mechanism of the antifibrotic effect of artesunate in pulmonary fibrosis (PF). Primary lung fibroblasts were isolated from the lung tissues of rats, and treated with artesunate (8 µg/ml) and transforming growth factor (TGF)-?1 (5 ng/ml). For in vivo experiments, the rats were administered bleomycin intratracheally, followed by daily intraperitoneal artesunate injections for 27 days. Western blotting, and immunohistochemical and immunofluorescent staining were used to assess the expression of key components of the Notch signaling pathway, including ?-smooth muscle actin (?-SMA) and type IV collagen. Artesunate (8 µg/ml) was identified to inhibit TGF-?1-induced ?-SMA and collagen protein expression, and repress the Notch signaling pathway, in primary lung fibroblasts. Downregulation of ?-SMA and collagen by artesunate was associated with inhibition of the Notch signaling pathway. The daily intraperitoneal injection of artesunate (1 mg/kg) in rats was determined to inhibit bleomycin-induced overexpression of ?-SMA and type IV collagen proteins, and inhibit the Notch signaling pathway, in lung tissues. In conclusion, the results of the current study indicate that artesunate inhibits the TGF-?1-induced differentiation of rat primary lung fibroblasts into myofibroblasts and ameliorates bleomycin-induced PF. In addition, the results of the present study suggest that the underlying molecular mechanism for these effects of artesunate is repression of the Notch signaling pathway. Twit Text FOAVip Artesunate ameliorates lung fibrosis via inhibiting the Notch signaling pathway ????Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=28672967 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28672967 #FOAvip English Wikipedia <ref>{{Cite pmid|28672967}}</ref> Artesunate ameliorates lung fibrosis via inhibiting the Notch signaling pathway #MMPMID28672967 Liu Y; Huang G; Mo B; Wang C Exp Ther Med 2017[Jul]; 14 (1): 561-6 PMID28672967show ga The present study aimed to determine the underlying molecular mechanism of the antifibrotic effect of artesunate in pulmonary fibrosis (PF). Primary lung fibroblasts were isolated from the lung tissues of rats, and treated with artesunate (8 µg/ml) and transforming growth factor (TGF)-?1 (5 ng/ml). For in vivo experiments, the rats were administered bleomycin intratracheally, followed by daily intraperitoneal artesunate injections for 27 days. Western blotting, and immunohistochemical and immunofluorescent staining were used to assess the expression of key components of the Notch signaling pathway, including ?-smooth muscle actin (?-SMA) and type IV collagen. Artesunate (8 µg/ml) was identified to inhibit TGF-?1-induced ?-SMA and collagen protein expression, and repress the Notch signaling pathway, in primary lung fibroblasts. Downregulation of ?-SMA and collagen by artesunate was associated with inhibition of the Notch signaling pathway. The daily intraperitoneal injection of artesunate (1 mg/kg) in rats was determined to inhibit bleomycin-induced overexpression of ?-SMA and type IV collagen proteins, and inhibit the Notch signaling pathway, in lung tissues. In conclusion, the results of the current study indicate that artesunate inhibits the TGF-?1-induced differentiation of rat primary lung fibroblasts into myofibroblasts and ameliorates bleomycin-induced PF. In addition, the results of the present study suggest that the underlying molecular mechanism for these effects of artesunate is repression of the Notch signaling pathway. äArtesunate ameliorates lung fibrosis via inhibiting the Notch signalin(epmc).pdf DeepDyve Pubget Overpricing