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10.3390/antiox6020029 http://scihub22266oqcxt.onion/10.3390/antiox6020029 C5488009!5488009!28475131     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antioxidants+(Basel) 2017 ; 6 (2): ä Nephropedia Template TP {{tp|p=28475131|t=2017. HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation |pdf=|usr=}}{{28475131}} gab.com Text HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation JO: Antioxidants (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28475131 #FOAvip The upregulation of heme oxygenase-1 (HO-1) is one of the most important mechanisms of cell adaptation to stress. Indeed, the redox sensitive transcription factor Nrf2 is the pivotal regulator of HO-1 induction. Through the antioxidant, antiapoptotic, and antinflammatory properties of its metabolic products, HO-1 plays a key role in healthy cells in maintaining redox homeostasis and in preventing carcinogenesis. Nevertheless, several lines of evidence have highlighted the role of HO-1 in cancer progression and its expression correlates with tumor growth, aggressiveness, metastatic and angiogenetic potential, resistance to therapy, tumor escape, and poor prognosis, even though a tumor- and tissue-specific activity has been observed. In this review, we summarize the current literature regarding the pro-tumorigenic role of HO-1 dependent tumor progression as a promising target in anticancer strategy. Twit Text FOAVip HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation ????Antioxidants (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28475131 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28475131 #FOAvip English Wikipedia <ref>{{Cite pmid|28475131}}</ref> HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation #MMPMID28475131 Nitti M; Piras S; Marinari UM; Moretta L; Pronzato MA; Furfaro AL Antioxidants (Basel) 2017[Jun]; 6 (2): ä PMID28475131show ga The upregulation of heme oxygenase-1 (HO-1) is one of the most important mechanisms of cell adaptation to stress. Indeed, the redox sensitive transcription factor Nrf2 is the pivotal regulator of HO-1 induction. Through the antioxidant, antiapoptotic, and antinflammatory properties of its metabolic products, HO-1 plays a key role in healthy cells in maintaining redox homeostasis and in preventing carcinogenesis. Nevertheless, several lines of evidence have highlighted the role of HO-1 in cancer progression and its expression correlates with tumor growth, aggressiveness, metastatic and angiogenetic potential, resistance to therapy, tumor escape, and poor prognosis, even though a tumor- and tissue-specific activity has been observed. In this review, we summarize the current literature regarding the pro-tumorigenic role of HO-1 dependent tumor progression as a promising target in anticancer strategy. äHO-1 Induction in Cancer Progression: A Matter of Cell Adaptation (epmc).pdf DeepDyve Pubget Overpricing