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10.1111/jcmm.13061 http://scihub22266oqcxt.onion/10.1111/jcmm.13061 C5487928!5487928 !28158917     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28158917 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Mol+Med 2017 ; 21 (7 ): 1315-1328 Nephropedia Template TP {{tp|p=28158917 |t=2017. Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling |pdf=|usr=}}{{28158917 }} gab.com Text Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28158917 #FOAvip Podocyte dysfunction results in glomerular diseases accounted for 90% of end-stage kidney disease. The evolutionarily conserved Notch signalling makes a crucial contribution in podocyte development and function. However, the underlying mechanism of Notch pathway modulating podocyte differentiation remains less obvious. Autophagy, reported to be related with Notch signalling pathways in different animal models, is regarded as a possible participant during podocyte differentiation. Here, we found the dynamic changes of Notch1 were coincided with autophagy: they both increased during kidney development and podocyte differentiation. Intriguingly, when Notch signalling was down-regulated by DAPT, autophagy was greatly diminished, and differentiation was also impaired. Further, to better understand the relationship between Notch signalling and autophagy in podocyte differentiation, rapamycin was added to enhance autophagy levels in DAPT-treated cells, and as a result, nephrin was recovered and DAPT-induced injury was ameliorated. Therefore, we put forward that autophagy is involved in kidney development and podocyte differentiation regulated by Notch signalling. Twit Text FOAVip Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28158917 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28158917 #FOAvip English Wikipedia <ref>{{Cite pmid|28158917 }}</ref> Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling #MMPMID28158917 Zhang C ; Li W ; Wen J ; Yang Z J Cell Mol Med 2017[Jul]; 21 (7 ): 1315-1328 PMID28158917 show ga Podocyte dysfunction results in glomerular diseases accounted for 90% of end-stage kidney disease. The evolutionarily conserved Notch signalling makes a crucial contribution in podocyte development and function. However, the underlying mechanism of Notch pathway modulating podocyte differentiation remains less obvious. Autophagy, reported to be related with Notch signalling pathways in different animal models, is regarded as a possible participant during podocyte differentiation. Here, we found the dynamic changes of Notch1 were coincided with autophagy: they both increased during kidney development and podocyte differentiation. Intriguingly, when Notch signalling was down-regulated by DAPT, autophagy was greatly diminished, and differentiation was also impaired. Further, to better understand the relationship between Notch signalling and autophagy in podocyte differentiation, rapamycin was added to enhance autophagy levels in DAPT-treated cells, and as a result, nephrin was recovered and DAPT-induced injury was ameliorated. Therefore, we put forward that autophagy is involved in kidney development and podocyte differentiation regulated by Notch signalling. |Animals [MESH] |Autophagy/*genetics [MESH] |Cell Differentiation/drug effects/genetics [MESH] |Diamines/pharmacology [MESH] |Kidney/*growth & development [MESH] |Membrane Proteins/*genetics [MESH] |Mice [MESH] |Podocytes/cytology/metabolism [MESH] |Receptor, Notch1/*genetics [MESH] |Signal Transduction/drug effects [MESH] |Sirolimus/pharmacology [MESH]Autophagy is involved in mouse kidney development and podocyte differe(epmc).pdf DeepDyve Pubget Overpricing