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10.1007/s00109-017-1550-4 http://scihub22266oqcxt.onion/10.1007/s00109-017-1550-4 C5487694!5487694!28597071     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28597071&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Med+(Berl) 2017 ; 95 (7): 695-703 Nephropedia Template TP {{tp|p=28597071|t=2017. The novel tool of cell reprogramming for applications in molecular medicine |pdf=|usr=}}{{28597071}} gab.com Text The novel tool of cell reprogramming for applications in molecular medicine JO: J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=28597071 #FOAvip Recent discoveries in the field of stem cell biology have enabled scientists to ?reprogram? cells from one type to another. For example, it is now possible to place adult skin or blood cells in a dish and convert them into neurons, liver, or heart cells. It is also possible to literally ?rejuvenate? adult cells by reprogramming them into embryonic-like stem cells, which in turn can be differentiated into every tissue and cell type of the human body. Our ability to reprogram cell types has four main implications for medicine: (1) scientists can now take skin or blood cells from patients and convert them to other cells to study disease processes. This disease modeling approach has the advantage over animal models because it is directly based on human patient cells. (2) Reprogramming could also be used as a ?clinical trial in a dish? to evaluate the general efficacy and safety of newly developed drugs on human patient cells before they would be tested in animal models or people. (3) In addition, many drugs have deleterious side effects like heart arrhythmias in only a small and unpredictable subpopulation of patients. Reprogramming could facilitate precision medicine by testing the safety of already approved drugs first on reprogrammed patient cells in a personalized manner prior to administration. For example, drugs known to sometimes cause arrhythmias could be first tested on reprogrammed heart cells from individual patients. (4) Finally, reprogramming allows the generation of new tissues that could be grafted therapeutically to regenerate lost or damaged cells. Twit Text FOAVip The novel tool of cell reprogramming for applications in molecular medicine ????J Mol Med (Berl) http://www.kidney.de/pget.php?&tw=1&pmid=28597071 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28597071 #FOAvip English Wikipedia <ref>{{Cite pmid|28597071}}</ref> The novel tool of cell reprogramming for applications in molecular medicine #MMPMID28597071 Mall M; Wernig M J Mol Med (Berl) 2017[]; 95 (7): 695-703 PMID28597071show ga Recent discoveries in the field of stem cell biology have enabled scientists to ?reprogram? cells from one type to another. For example, it is now possible to place adult skin or blood cells in a dish and convert them into neurons, liver, or heart cells. It is also possible to literally ?rejuvenate? adult cells by reprogramming them into embryonic-like stem cells, which in turn can be differentiated into every tissue and cell type of the human body. Our ability to reprogram cell types has four main implications for medicine: (1) scientists can now take skin or blood cells from patients and convert them to other cells to study disease processes. This disease modeling approach has the advantage over animal models because it is directly based on human patient cells. (2) Reprogramming could also be used as a ?clinical trial in a dish? to evaluate the general efficacy and safety of newly developed drugs on human patient cells before they would be tested in animal models or people. (3) In addition, many drugs have deleterious side effects like heart arrhythmias in only a small and unpredictable subpopulation of patients. Reprogramming could facilitate precision medicine by testing the safety of already approved drugs first on reprogrammed patient cells in a personalized manner prior to administration. For example, drugs known to sometimes cause arrhythmias could be first tested on reprogrammed heart cells from individual patients. (4) Finally, reprogramming allows the generation of new tissues that could be grafted therapeutically to regenerate lost or damaged cells. äThe novel tool of cell reprogramming for applications in molecular med(epmc).pdf DeepDyve Pubget Overpricing