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10.1016/j.gpb.2016.12.005

http://scihub22266oqcxt.onion/10.1016/j.gpb.2016.12.005
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pmid28529100      Genomics+Proteomics+Bioinformatics 2017 ; 15 (3): 177-86
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  • Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA #MMPMID28529100
  • Dykes IM; Emanueli C
  • Genomics Proteomics Bioinformatics 2017[Jun]; 15 (3): 177-86 PMID28529100show ga
  • Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA (miRNA) pathways. lncRNA has been shown to act as both a source and an inhibitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying complexes by directing them to specific loci.
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