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10.3389/fimmu.2017.00760 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00760 C5487399!5487399!28702032     free     free     free       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28702032|t=2017. NK Cell Exhaustion |pdf=|usr=}}{{28702032}} gab.com Text NK Cell Exhaustion JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28702032 #FOAvip Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells. In many tumors or chronic infections, multiple mechanisms might contribute to the exhaustion of NK cells, such as dysregulated NK cell receptors signaling, as well as suppressive effects by regulatory cells or soluble factors within the microenvironment. Better understanding of the characteristics, as well as the underlying mechanisms of NK cell exhaustion, not only should increase our understanding of the basic biology of NK cells but also could reveal novel NK cell-based antitumor/infection targets. Here, we provide an overview of our current knowledge on NK cell exhaustion in tumors, and in chronic infections. Twit Text FOAVip NK Cell Exhaustion ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28702032 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28702032 #FOAvip English Wikipedia <ref>{{Cite pmid|28702032}}</ref> NK Cell Exhaustion #MMPMID28702032 Bi J; Tian Z Front Immunol 2017[]; 8 (ä): ä PMID28702032show ga Natural killer cells are important effector lymphocytes of the innate immune system, playing critical roles in antitumor and anti-infection host defense. Tumor progression or chronic infections, however, usually leads to exhaustion of NK cells, thus limiting the antitumor/infection potential of NK cells. In many tumors or chronic infections, multiple mechanisms might contribute to the exhaustion of NK cells, such as dysregulated NK cell receptors signaling, as well as suppressive effects by regulatory cells or soluble factors within the microenvironment. Better understanding of the characteristics, as well as the underlying mechanisms of NK cell exhaustion, not only should increase our understanding of the basic biology of NK cells but also could reveal novel NK cell-based antitumor/infection targets. Here, we provide an overview of our current knowledge on NK cell exhaustion in tumors, and in chronic infections. äNK Cell Exhaustion (epmc).pdf DeepDyve Pubget Overpricing