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10.5500/wjt.v7.i3.179 http://scihub22266oqcxt.onion/10.5500/wjt.v7.i3.179 C5487308!5487308!28698835     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Transplant 2017 ; 7 (3): 179-92 Nephropedia Template TP {{tp|p=28698835|t=2017. Historical perspective of cell transplantation in Parkinson?s disease |pdf=|usr=}}{{28698835}} gab.com Text Historical perspective of cell transplantation in Parkinson s disease JO: World J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=28698835 #FOAvip Cell grafting has been considered a therapeutic approach for Parkinson?s disease (PD) since the 1980s. The classical motor symptoms of PD are caused by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to a decrement in dopamine release in the striatum. Consequently, the therapy of cell-transplantation for PD consists in grafting dopamine-producing cells directly into the brain to reestablish dopamine levels. Different cell sources have been shown to induce functional benefits on both animal models of PD and human patients. However, the observed motor improvements are highly variable between individual subjects, and the sources of this variability are not fully understood. The purpose of this review is to provide a general overview of the pioneering studies done in animal models of PD that established the basis for the first clinical trials in humans, and compare these with the latest findings to identify the most relevant aspects that remain unanswered to date. The main focus of the discussions presented here will be on the mechanisms associated with the survival and functionality of the transplants. These include the role of the dopamine released by the grafts and the capacity of the grafted cells to extend fibers and to integrate into the motor circuit. The complete understanding of these aspects will require extensive research on basic aspects of molecular and cellular physiology, together with neuronal network function, in order to uncover the real potential of cell grafting for treating PD. Twit Text FOAVip Historical perspective of cell transplantation in Parkinson s disease ????World J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=28698835 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28698835 #FOAvip English Wikipedia <ref>{{Cite pmid|28698835}}</ref> Historical perspective of cell transplantation in Parkinson?s disease #MMPMID28698835 Boronat-García A; Guerra-Crespo M; Drucker-Colín R World J Transplant 2017[Jun]; 7 (3): 179-92 PMID28698835show ga Cell grafting has been considered a therapeutic approach for Parkinson?s disease (PD) since the 1980s. The classical motor symptoms of PD are caused by the loss of dopaminergic neurons in the substantia nigra pars compacta, leading to a decrement in dopamine release in the striatum. Consequently, the therapy of cell-transplantation for PD consists in grafting dopamine-producing cells directly into the brain to reestablish dopamine levels. Different cell sources have been shown to induce functional benefits on both animal models of PD and human patients. However, the observed motor improvements are highly variable between individual subjects, and the sources of this variability are not fully understood. The purpose of this review is to provide a general overview of the pioneering studies done in animal models of PD that established the basis for the first clinical trials in humans, and compare these with the latest findings to identify the most relevant aspects that remain unanswered to date. The main focus of the discussions presented here will be on the mechanisms associated with the survival and functionality of the transplants. These include the role of the dopamine released by the grafts and the capacity of the grafted cells to extend fibers and to integrate into the motor circuit. The complete understanding of these aspects will require extensive research on basic aspects of molecular and cellular physiology, together with neuronal network function, in order to uncover the real potential of cell grafting for treating PD. äHistorical perspective of cell transplantation in Parkinson?s disease (epmc).pdf DeepDyve Pubget Overpricing