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10.1007/s00259-017-3683-7

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suck abstract from ncbi


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pmid28451827
      Eur+J+Nucl+Med+Mol+Imaging 2017 ; 44 (8 ): 1393-1407
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  • Accuracy of diagnostic imaging modalities for peripheral post-traumatic osteomyelitis - a systematic review of the recent literature #MMPMID28451827
  • Govaert GA ; IJpma FF ; McNally M ; McNally E ; Reininga IH ; Glaudemans AW
  • Eur J Nucl Med Mol Imaging 2017[Aug]; 44 (8 ): 1393-1407 PMID28451827 show ga
  • AIMS: Post-traumatic osteomyelitis (PTO) is difficult to diagnose and there is no consensus on the best imaging strategy. The aim of this study is to present a systematic review of the recent literature on diagnostic imaging of PTO. METHODS: A literature search of the EMBASE and PubMed databases of the last 16 years (2000-2016) was performed. Studies that evaluated the accuracy of magnetic resonance imaging (MRI), three-phase bone scintigraphy (TPBS), white blood cell (WBC) or antigranulocyte antibody (AGA) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and plain computed tomography (CT) in diagnosing PTO were considered for inclusion. The review was conducted using the PRISMA statement and QUADAS-2 criteria. RESULTS: The literature search identified 3358 original records, of which 10 articles could be included in this review. Four of these studies had a comparative design which made it possible to report the results of, in total, 17 patient series. WBC (or AGA) scintigraphy and FDG-PET exhibit good accuracy for diagnosing PTO (sensitivity ranged from 50-100%, specificity ranged from 40-97% versus 83-100% and 51%-100%, respectively). The accuracy of both modalities improved when a hybrid imaging technique (SPECT/CT & FDG-PET/CT) was performed. For FDG-PET/CT, sensitivity ranged between 86 and 94% and specificity between 76 and 100%. For WBC scintigraphy?+?SPECT/CT, this is 100% and 89-97%, respectively. CONCLUSIONS: Based on the best available evidence of the last 16 years, both WBC (or AGA) scintigraphy combined with SPECT/CT or FDG-PET combined with CT have the best diagnostic accuracy for diagnosing peripheral PTO.
  • |Diagnostic Imaging/*methods [MESH]
  • |Humans [MESH]
  • |Osteomyelitis/*complications/*diagnostic imaging [MESH]
  • |Sensitivity and Specificity [MESH]


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