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2017 ; 44
(8
): 1393-1407
Nephropedia Template TP
gab.com Text
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English Wikipedia
Accuracy of diagnostic imaging modalities for peripheral post-traumatic
osteomyelitis - a systematic review of the recent literature
#MMPMID28451827
Govaert GA
; IJpma FF
; McNally M
; McNally E
; Reininga IH
; Glaudemans AW
Eur J Nucl Med Mol Imaging
2017[Aug]; 44
(8
): 1393-1407
PMID28451827
show ga
AIMS: Post-traumatic osteomyelitis (PTO) is difficult to diagnose and there is no
consensus on the best imaging strategy. The aim of this study is to present a
systematic review of the recent literature on diagnostic imaging of PTO. METHODS:
A literature search of the EMBASE and PubMed databases of the last 16 years
(2000-2016) was performed. Studies that evaluated the accuracy of magnetic
resonance imaging (MRI), three-phase bone scintigraphy (TPBS), white blood cell
(WBC) or antigranulocyte antibody (AGA) scintigraphy, fluorodeoxyglucose positron
emission tomography (FDG-PET) and plain computed tomography (CT) in diagnosing
PTO were considered for inclusion. The review was conducted using the PRISMA
statement and QUADAS-2 criteria. RESULTS: The literature search identified 3358
original records, of which 10 articles could be included in this review. Four of
these studies had a comparative design which made it possible to report the
results of, in total, 17 patient series. WBC (or AGA) scintigraphy and FDG-PET
exhibit good accuracy for diagnosing PTO (sensitivity ranged from 50-100%,
specificity ranged from 40-97% versus 83-100% and 51%-100%, respectively). The
accuracy of both modalities improved when a hybrid imaging technique (SPECT/CT &
FDG-PET/CT) was performed. For FDG-PET/CT, sensitivity ranged between 86 and 94%
and specificity between 76 and 100%. For WBC scintigraphy?+?SPECT/CT, this is
100% and 89-97%, respectively. CONCLUSIONS: Based on the best available evidence
of the last 16 years, both WBC (or AGA) scintigraphy combined with SPECT/CT or
FDG-PET combined with CT have the best diagnostic accuracy for diagnosing
peripheral PTO.