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Accuracy of diagnostic imaging modalities for peripheral post-traumatic osteomyelitis ? a systematic review of the recent literature #MMPMID28451827
Govaert GA; IJpma FF; McNally M; McNally E; Reininga IH; Glaudemans AW
Eur J Nucl Med Mol Imaging 2017[]; 44 (8): 1393-407 PMID28451827show ga
Aims: Post-traumatic osteomyelitis (PTO) is difficult to diagnose and there is no consensus on the best imaging strategy. The aim of this study is to present a systematic review of the recent literature on diagnostic imaging of PTO. Methods: A literature search of the EMBASE and PubMed databases of the last 16 years (2000?2016) was performed. Studies that evaluated the accuracy of magnetic resonance imaging (MRI), three-phase bone scintigraphy (TPBS), white blood cell (WBC) or antigranulocyte antibody (AGA) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and plain computed tomography (CT) in diagnosing PTO were considered for inclusion. The review was conducted using the PRISMA statement and QUADAS-2 criteria. Results: The literature search identified 3358 original records, of which 10 articles could be included in this review. Four of these studies had a comparative design which made it possible to report the results of, in total, 17 patient series. WBC (or AGA) scintigraphy and FDG-PET exhibit good accuracy for diagnosing PTO (sensitivity ranged from 50?100%, specificity ranged from 40?97% versus 83?100% and 51%?100%, respectively). The accuracy of both modalities improved when a hybrid imaging technique (SPECT/CT & FDG-PET/CT) was performed. For FDG-PET/CT, sensitivity ranged between 86 and 94% and specificity between 76 and 100%. For WBC scintigraphy?+?SPECT/CT, this is 100% and 89?97%, respectively. Conclusions: Based on the best available evidence of the last 16 years, both WBC (or AGA) scintigraphy combined with SPECT/CT or FDG-PET combined with CT have the best diagnostic accuracy for diagnosing peripheral PTO.