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10.1080/15548627.2017.1307486 http://scihub22266oqcxt.onion/10.1080/15548627.2017.1307486 C5486376!5486376!28368721     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2017 ; 13 (6): 1084-5 Nephropedia Template TP {{tp|p=28368721|t=2017. Cellular and molecular mechanism for secretory autophagy |pdf=|usr=}}{{28368721}} gab.com Text Cellular and molecular mechanism for secretory autophagy JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=28368721 #FOAvip Macroautophagy/autophagy plays a role in unconventional secretion of leaderless cytosolic proteins. Whether and how secretory autophagy diverges from conventional degradative autophagy is unclear. We have shown that the prototypical secretory autophagy cargo IL1B/IL-1? (interleukin 1 ?) is recognized by TRIM16, and that this first to be identified secretory autophagy receptor interacts with the R-SNARE SEC22B to jointly deliver cargo to the MAP1LC3B-II-positive sequestration membranes. Cargo secretion is unaffected by knockdowns of STX17, a SNARE catalyzing autophagosome-lysosome fusion as a prelude to cargo degradation. Instead, SEC22B in combination with plasma membrane syntaxins completes cargo secretion. Thus, secretory autophagy diverges from degradative autophagy by using specialized receptors and a dedicated SNARE machinery to bypass fusion with lysosomes. Twit Text FOAVip Cellular and molecular mechanism for secretory autophagy ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=28368721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28368721 #FOAvip English Wikipedia <ref>{{Cite pmid|28368721}}</ref> Cellular and molecular mechanism for secretory autophagy #MMPMID28368721 Kimura T; Jia J; Claude-Taupin A; Kumar S; Choi SW; Gu Y; Mudd M; Dupont N; Jiang S; Peters R; Farzam F; Jain A; Lidke KA; Adams CM; Johansen T; Deretic V Autophagy 2017[]; 13 (6): 1084-5 PMID28368721show ga Macroautophagy/autophagy plays a role in unconventional secretion of leaderless cytosolic proteins. Whether and how secretory autophagy diverges from conventional degradative autophagy is unclear. We have shown that the prototypical secretory autophagy cargo IL1B/IL-1? (interleukin 1 ?) is recognized by TRIM16, and that this first to be identified secretory autophagy receptor interacts with the R-SNARE SEC22B to jointly deliver cargo to the MAP1LC3B-II-positive sequestration membranes. Cargo secretion is unaffected by knockdowns of STX17, a SNARE catalyzing autophagosome-lysosome fusion as a prelude to cargo degradation. Instead, SEC22B in combination with plasma membrane syntaxins completes cargo secretion. Thus, secretory autophagy diverges from degradative autophagy by using specialized receptors and a dedicated SNARE machinery to bypass fusion with lysosomes. äCellular and molecular mechanism for secretory autophagy (epmc).pdf DeepDyve Pubget Overpricing