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10.1080/15548627.2017.1300224 http://scihub22266oqcxt.onion/10.1080/15548627.2017.1300224 C5486361!5486361 !28323531     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28323531 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury |pdf=|usr=}}{{28323531 }} gab.com Text Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=28323531 #FOAvip Mitophagy plays pivotal roles in the selective disposal of unwanted mitochondria, and accumulation of damaged mitochondria has been linked to aging-related diseases. However, definitive proof that mitophagy regulates mitochondrial quality in vivo is lacking. It is also largely unclear whether damaged mitochondria are the cause or just the consequence of these diseases. We previously showed that FUNDC1 is a mitophagy receptor that interacts with LC3 to mediate mitophagy in response to hypoxia in cultured cells. We established Fundc1 knockout mouse models and used genetic and biochemical approaches, including a synthetic peptide that blocks the FUNDC1-LC3 interaction, to demonstrate that mitophagy regulates both mitochondrial quantity and quality in vivo in response to hypoxia or hypoxic conditions caused by ischemia-reperfusion (I/R) heart injury. We found that hypoxic mitophagy regulates platelet activities. Furthermore, we found that hypoxic preconditioning induces FUNDC1-dependent mitophagy in platelets and reduces I/R-induced heart injury, suggesting a new strategy to protect cardiac function and fight cardiovascular diseases. Twit Text FOAVip Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=28323531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28323531 #FOAvip English Wikipedia <ref>{{Cite pmid|28323531 }}</ref> Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury #MMPMID28323531 Zhang W ; Siraj S ; Zhang R ; Chen Q Autophagy 2017[Jun]; 13 (6 ): 1080-1081 PMID28323531 show ga Mitophagy plays pivotal roles in the selective disposal of unwanted mitochondria, and accumulation of damaged mitochondria has been linked to aging-related diseases. However, definitive proof that mitophagy regulates mitochondrial quality in vivo is lacking. It is also largely unclear whether damaged mitochondria are the cause or just the consequence of these diseases. We previously showed that FUNDC1 is a mitophagy receptor that interacts with LC3 to mediate mitophagy in response to hypoxia in cultured cells. We established Fundc1 knockout mouse models and used genetic and biochemical approaches, including a synthetic peptide that blocks the FUNDC1-LC3 interaction, to demonstrate that mitophagy regulates both mitochondrial quantity and quality in vivo in response to hypoxia or hypoxic conditions caused by ischemia-reperfusion (I/R) heart injury. We found that hypoxic mitophagy regulates platelet activities. Furthermore, we found that hypoxic preconditioning induces FUNDC1-dependent mitophagy in platelets and reduces I/R-induced heart injury, suggesting a new strategy to protect cardiac function and fight cardiovascular diseases. |*Homeostasis [MESH] |*Mitophagy [MESH] |Animals [MESH] |Membrane Proteins/*metabolism [MESH] |Mice, Knockout [MESH] |Mitochondria/*metabolism [MESH] |Mitochondrial Proteins/*metabolism [MESH] |Models, Biological [MESH] |Myocardium/*metabolism/*pathology [MESH]Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and prot(epmc).pdf DeepDyve Pubget Overpricing