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2017 ; 14
(6
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Ephedra-Treated Donor-Derived Gut Microbiota Transplantation Ameliorates High Fat
Diet-Induced Obesity in Rats
#MMPMID28545248
Wang JH
; Kim BS
; Han K
; Kim H
Int J Environ Res Public Health
2017[May]; 14
(6
): ä PMID28545248
show ga
Changes in gut microbiota (GM) are closely associated with metabolic syndrome,
obesity, type 2 diabetes and so on. Several medicinal herbs, including Ephedra
sinica (Es), have anti-obesity effects that ameliorate metabolic disorders.
Therefore, in this study we evaluated whether Es maintains its anti-obesity
effect through Es-altered gut microbiota (EsM) transplantation. GM was isolated
from cecal contents of Es treated and untreated rats following repeated
transplants into obese rats via oral gavage over three weeks. High-fat-diet
(HFD)-induced obese rats transplanted with EsM lost significant body weight,
epididymal fat, and perirenal fat weight, but no remarkable changes were observed
in abdominal fat, liver, cecum weight and food efficiency ratio. In addition,
treatment with EsM also significantly lowered the fasting blood glucose, serum
insulin level, and insulin resistance index. Meanwhile, EsM transplantation
significantly reduced gene expression of proinflammatory cytokines interleukin-1
and monocyte chemotactic protein-1. Rats treated with EsM also showed changed GM
composition, especially blautia, roseburia and clostridium, significantly reduced
the level of endotoxin and markedly increased the acetic acid in feces. Overall,
our results demonstrated that EsM ameliorates HFD-induced obesity and related
metabolic disorders, like hyperglycemia and insulin resistance, and is strongly
associated with modulating the distribution of GM, enterogenous endotoxin and
enteral acetic acid.