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10.1001/jama.2016.14380 http://scihub22266oqcxt.onion/10.1001/jama.2016.14380 C5486217!5486217!27701659     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JAMA 2016 ; 316 (13): 1375-82 Nephropedia Template TP {{tp|p=27701659|t=2016. Association Between Therapeutic Hypothermia and Survival After In-Hospital Cardiac Arrest: Hypothermia after in-hospital cardiac arrest |pdf=|usr=}}{{27701659}} gab.com Text Association Between Therapeutic Hypothermia and Survival After In-Hospital Cardiac Arrest: Hypothermia after in-hospital cardiac arrest JO: JAMA http://www.kidney.de/pget.php?&tw=1&pmid=27701659 #FOAvip Context: Therapeutic hypothermia is used for patients following both out-of-hospital and in-hospital cardiac arrest. However, randomized trials on its efficacy for the in-hospital setting do not exist, and comparativeness effectiveness data are limited. Objective: To evaluate the association between therapeutic hypothermia and survival after in-hospital cardiac arrest. Design, Setting, Patients: Within the national Get-With-The-Guidelines-Resuscitation registry, 26,183 patients successfully resuscitated from an in-hospital cardiac arrest between March 1, 2002 and December 31, 2014 following introduction of therapeutic hypothermia treatment at 355 U.S. hospitals were identified. Follow-up ended February 4, 2015. Exposure: Induction of therapeutic hypothermia Main Outcome Measures: Primary outcome of survival to hospital discharge. Secondary outcome of favorable neurological survival, defined as a cerebral performance category score ? 2 (i.e., without severe neurological disability). Comparisons were performed using a matched propensity score analysis and examined for all arrests, and separately for nonshockable (asystole and pulseless electrical activity) and shockable cardiac arrests (ventricular fibrillation and pulseless ventricular tachycardia). Results: Overall, 1568 (6.0%) patients with in-hospital cardiac arrest were treated with therapeutic hypothermia, and 1524 patients were matched by propensity score to 3714 non-hypothermia-treated patients. Mean age of the propensity score-matched cohort was 62.0 ± 17.5 years, 57.5% were men, and 68.0% were white. After adjustment, therapeutic hypothermia was associated with lower in-hospital survival (27.4% vs. 29.2%; Relative Risk, 0.88 [95% CI, 0.80?0.97]; Risk Difference, ?3.6% [?6.3%, ?0.9%]; P=0.01), and these associations were similar (interaction P=0.74) for non-shockable (22.2% vs. 24.5%; Relative Risk, 0.87 [0.76?0.99]; Risk Difference, ?3.2% [?6.2%, ?0.3%]) and shockable cardiac arrest rhythms (41.3% vs. 44.1%; Relative Risk, 0.90 [0.77, 1.05]; Risk Difference, ?4.6% [?10.9%, 1.7%]). Therapeutic hypothermia was also associated with lower rates of favorable neurological survival for the overall cohort (hypothermia group, 17.0% [246/1443]; non-hypothermia group, 20.5% [725/3529]; Relative Risk, 0.79 [0.69, 0.90]; Risk Difference, ?4.4% [?6.8%, ?2.0%]; P<0.001) and for both rhythm types (interaction P=0.88). Conclusion: Among patients with in-hospital cardiac arrest, use of therapeutic hypothermia compared with usual care was associated with a lower likelihood of survival to hospital discharge and a lower likelihood of favorable neurological survival. These observational findings warrant a randomized clinical trial to assess efficacy of therapeutic hypothermia for in-hospital cardiac arrest. Twit Text FOAVip Association Between Therapeutic Hypothermia and Survival After In-Hospital Cardiac Arrest: Hypothermia after in-hospital cardiac arrest ????JAMA http://www.kidney.de/pget.php?&tw=1&pmid=27701659 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27701659 #FOAvip English Wikipedia <ref>{{Cite pmid|27701659}}</ref> Association Between Therapeutic Hypothermia and Survival After In-Hospital Cardiac Arrest: Hypothermia after in-hospital cardiac arrest #MMPMID27701659 Chan PS; Berg RA; Tang Y; Curtis LH; Spertus JA JAMA 2016[Oct]; 316 (13): 1375-82 PMID27701659show ga Context: Therapeutic hypothermia is used for patients following both out-of-hospital and in-hospital cardiac arrest. However, randomized trials on its efficacy for the in-hospital setting do not exist, and comparativeness effectiveness data are limited. Objective: To evaluate the association between therapeutic hypothermia and survival after in-hospital cardiac arrest. Design, Setting, Patients: Within the national Get-With-The-Guidelines-Resuscitation registry, 26,183 patients successfully resuscitated from an in-hospital cardiac arrest between March 1, 2002 and December 31, 2014 following introduction of therapeutic hypothermia treatment at 355 U.S. hospitals were identified. Follow-up ended February 4, 2015. Exposure: Induction of therapeutic hypothermia Main Outcome Measures: Primary outcome of survival to hospital discharge. Secondary outcome of favorable neurological survival, defined as a cerebral performance category score ? 2 (i.e., without severe neurological disability). Comparisons were performed using a matched propensity score analysis and examined for all arrests, and separately for nonshockable (asystole and pulseless electrical activity) and shockable cardiac arrests (ventricular fibrillation and pulseless ventricular tachycardia). Results: Overall, 1568 (6.0%) patients with in-hospital cardiac arrest were treated with therapeutic hypothermia, and 1524 patients were matched by propensity score to 3714 non-hypothermia-treated patients. Mean age of the propensity score-matched cohort was 62.0 ± 17.5 years, 57.5% were men, and 68.0% were white. After adjustment, therapeutic hypothermia was associated with lower in-hospital survival (27.4% vs. 29.2%; Relative Risk, 0.88 [95% CI, 0.80?0.97]; Risk Difference, ?3.6% [?6.3%, ?0.9%]; P=0.01), and these associations were similar (interaction P=0.74) for non-shockable (22.2% vs. 24.5%; Relative Risk, 0.87 [0.76?0.99]; Risk Difference, ?3.2% [?6.2%, ?0.3%]) and shockable cardiac arrest rhythms (41.3% vs. 44.1%; Relative Risk, 0.90 [0.77, 1.05]; Risk Difference, ?4.6% [?10.9%, 1.7%]). Therapeutic hypothermia was also associated with lower rates of favorable neurological survival for the overall cohort (hypothermia group, 17.0% [246/1443]; non-hypothermia group, 20.5% [725/3529]; Relative Risk, 0.79 [0.69, 0.90]; Risk Difference, ?4.4% [?6.8%, ?2.0%]; P<0.001) and for both rhythm types (interaction P=0.88). Conclusion: Among patients with in-hospital cardiac arrest, use of therapeutic hypothermia compared with usual care was associated with a lower likelihood of survival to hospital discharge and a lower likelihood of favorable neurological survival. These observational findings warrant a randomized clinical trial to assess efficacy of therapeutic hypothermia for in-hospital cardiac arrest. äAssociation Between Therapeutic Hypothermia and Survival After In-Hosp(epmc).pdf DeepDyve Pubget Overpricing