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10.1080/2162402X.2017.1323155 http://scihub22266oqcxt.onion/10.1080/2162402X.2017.1323155 C5486190!5486190 !28680761     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28680761 &cmd=llinks): Failed to open stream: HTTP request failed! 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The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival |pdf=|usr=}}{{28680761 }} gab.com Text The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=28680761 #FOAvip Microenvironmental regulation in lymphoid tissues is essential for the development of chronic lymphocytic leukemia. We identified cellular and molecular factors provided by the splenic marginal zone (MZ), which alter the migratory and adhesive behavior of leukemic cells. We used the Cxcr5(-/-)Eµ-Tcl1 leukemia mouse model, in which tumor cells are excluded from B cell follicles and instead accumulate within the MZ. Genes involved in MZ B cell development and genes encoding for adhesion molecules were upregulated in MZ-localized Cxcr5(-/-)Eµ-Tcl1 cells. Likewise, surface expression of the adhesion and homing molecules, CD49d/VLA-4 and CXCR7, and of NOTCH2 was increased. In vitro, exposing Eµ-Tcl1 cells or human CLL cells to niche-specific stimuli, like B cell receptor- or Toll-like receptor ligands, caused surface expression of these molecules characteristic for a follicular or MZ-like microenvironment, respectively. In vivo, inhibition of VLA-4-mediated adhesion and CXCL13-mediated follicular homing displaced leukemic cells not only from the follicle, but also from the MZ and reduced leukemia progression. We conclude that MZ-specific factors shape the phenotype of leukemic cells and facilitate their niche-specific retention. This strong microenvironmental influence gains pathogenic significance independent from tumor-specific genetic aberrations. Twit Text FOAVip The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=28680761 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28680761 #FOAvip English Wikipedia <ref>{{Cite pmid|28680761 }}</ref> The splenic marginal zone shapes the phenotype of leukemia B cells and facilitates their niche-specific retention and survival #MMPMID28680761 Stache V ; Verlaat L ; Gätjen M ; Heinig K ; Westermann J ; Rehm A ; Höpken UE Oncoimmunology 2017[]; 6 (6 ): e1323155 PMID28680761 show ga Microenvironmental regulation in lymphoid tissues is essential for the development of chronic lymphocytic leukemia. We identified cellular and molecular factors provided by the splenic marginal zone (MZ), which alter the migratory and adhesive behavior of leukemic cells. We used the Cxcr5(-/-)Eµ-Tcl1 leukemia mouse model, in which tumor cells are excluded from B cell follicles and instead accumulate within the MZ. Genes involved in MZ B cell development and genes encoding for adhesion molecules were upregulated in MZ-localized Cxcr5(-/-)Eµ-Tcl1 cells. Likewise, surface expression of the adhesion and homing molecules, CD49d/VLA-4 and CXCR7, and of NOTCH2 was increased. In vitro, exposing Eµ-Tcl1 cells or human CLL cells to niche-specific stimuli, like B cell receptor- or Toll-like receptor ligands, caused surface expression of these molecules characteristic for a follicular or MZ-like microenvironment, respectively. In vivo, inhibition of VLA-4-mediated adhesion and CXCL13-mediated follicular homing displaced leukemic cells not only from the follicle, but also from the MZ and reduced leukemia progression. We conclude that MZ-specific factors shape the phenotype of leukemic cells and facilitate their niche-specific retention. This strong microenvironmental influence gains pathogenic significance independent from tumor-specific genetic aberrations. äThe splenic marginal zone shapes the phenotype of leukemia B cells and(epmc).pdf DeepDyve Pubget Overpricing