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10.1080/2162402X.2017.1319027 http://scihub22266oqcxt.onion/10.1080/2162402X.2017.1319027 C5486184!5486184 !28680752     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28680752 &cmd=llinks): Failed to open stream: HTTP request failed! 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Oral IL-10 suppresses colon carcinogenesis via elimination of pathogenicCD4(+) T-cells and induction of antitumor CD8(+) T-cell activity |pdf=|usr=}}{{28680752 }} gab.com Text Oral IL-10 suppresses colon carcinogenesis via elimination of pathogenicCD4(+) T-cells and induction of antitumor CD8(+) T-cell activity JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=28680752 #FOAvip An oral sustained-release formulation of Interleukin-10 suppressed tumor growth and enhanced survival in the APC(min/+)/Bacteroides fragilis spontaneous colon cancer model. Therapeutic benefit was associated with a 5-fold reduction in CD4(+)ROR?t(+)Foxp3(-)IL-17(+) T-helper cell, CD4(+)ROR?t(+)Foxp3(+)IL-17(+) pathogenic T-regulatory cell and CD4(+)ROR?t(-)Foxp3(+)IL-17(-) conventional T-regulatory cell numbers and a concurrent 2-fold enhancement in CD8(+) T-cell activity in the colon. Selective subset depletion and functional blockade studies demonstrated that at steady-state CD4(+)ROR?t(+)IL-17(+) T-cell subsets and CD4(+)Foxp3(+) cTreg supported tumorigenesis, whereas CD8(+) cytotoxic T-lymphocytes impeded tumor progression following IL-10 therapy. Suppression of tumor growth by CD8(+) T-cells was associated with enhanced tumor infiltration and cytotoxic granule exocytosis. These findings establish the utility of oral IL-10 as a potential new therapeutic in the management of colon cancer and shed light on the cellular mechanisms that underlie its antitumor activity. Twit Text FOAVip Oral IL-10 suppresses colon carcinogenesis via elimination of pathogenicCD4(+) T-cells and induction of antitumor CD8(+) T-cell activity ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=28680752 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28680752 #FOAvip English Wikipedia <ref>{{Cite pmid|28680752 }}</ref> Oral IL-10 suppresses colon carcinogenesis via elimination of pathogenicCD4(+) T-cells and induction of antitumor CD8(+) T-cell activity #MMPMID28680752 Gu T ; De Jesus M ; Gallagher HC ; Burris TP ; Egilmez NK Oncoimmunology 2017[]; 6 (6 ): e1319027 PMID28680752 show ga An oral sustained-release formulation of Interleukin-10 suppressed tumor growth and enhanced survival in the APC(min/+)/Bacteroides fragilis spontaneous colon cancer model. Therapeutic benefit was associated with a 5-fold reduction in CD4(+)ROR?t(+)Foxp3(-)IL-17(+) T-helper cell, CD4(+)ROR?t(+)Foxp3(+)IL-17(+) pathogenic T-regulatory cell and CD4(+)ROR?t(-)Foxp3(+)IL-17(-) conventional T-regulatory cell numbers and a concurrent 2-fold enhancement in CD8(+) T-cell activity in the colon. Selective subset depletion and functional blockade studies demonstrated that at steady-state CD4(+)ROR?t(+)IL-17(+) T-cell subsets and CD4(+)Foxp3(+) cTreg supported tumorigenesis, whereas CD8(+) cytotoxic T-lymphocytes impeded tumor progression following IL-10 therapy. Suppression of tumor growth by CD8(+) T-cells was associated with enhanced tumor infiltration and cytotoxic granule exocytosis. These findings establish the utility of oral IL-10 as a potential new therapeutic in the management of colon cancer and shed light on the cellular mechanisms that underlie its antitumor activity. äOral IL-10 suppresses colon carcinogenesis via elimination of pathogen(epmc).pdf DeepDyve Pubget Overpricing