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10.3390/ijms18061279 http://scihub22266oqcxt.onion/10.3390/ijms18061279 C5486101!5486101!28621712     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2017 ; 18 (6): ä Nephropedia Template TP {{tp|p=28621712|t=2017. Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors |pdf=|usr=}}{{28621712}} gab.com Text Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28621712 #FOAvip Eukaryotes use autophagy as a mechanism for maintaining cellular homeostasis by degrading and recycling organelles and proteins. This process assists in the proliferation and survival of advanced cancers. There is mounting preclinical evidence that targeting autophagy can enhance the efficacy of many cancer therapies. Hydroxychloroquine (HCQ) is the only clinically-approved autophagy inhibitor, and this systematic review focuses on HCQ use in cancer clinical trials. Preclinical trials have shown that HCQ alone and in combination therapy leads to enhancement of tumor shrinkage. This has provided the base for multiple ongoing clinical trials involving HCQ alone and in combination with other treatments. However, due to its potency, there is still a need for more potent and specific autophagy inhibitors. There are multiple autophagy inhibitors in the pre-clinical stage at various stages of development. Additional studies on the mechanism of HCQ and other autophagy inhibitors are still required to answer questions surrounding how these agents will eventually be used in the clinic. Twit Text FOAVip Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28621712 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28621712 #FOAvip English Wikipedia <ref>{{Cite pmid|28621712}}</ref> Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors #MMPMID28621712 Chude CI; Amaravadi RK Int J Mol Sci 2017[Jun]; 18 (6): ä PMID28621712show ga Eukaryotes use autophagy as a mechanism for maintaining cellular homeostasis by degrading and recycling organelles and proteins. This process assists in the proliferation and survival of advanced cancers. There is mounting preclinical evidence that targeting autophagy can enhance the efficacy of many cancer therapies. Hydroxychloroquine (HCQ) is the only clinically-approved autophagy inhibitor, and this systematic review focuses on HCQ use in cancer clinical trials. Preclinical trials have shown that HCQ alone and in combination therapy leads to enhancement of tumor shrinkage. This has provided the base for multiple ongoing clinical trials involving HCQ alone and in combination with other treatments. However, due to its potency, there is still a need for more potent and specific autophagy inhibitors. There are multiple autophagy inhibitors in the pre-clinical stage at various stages of development. Additional studies on the mechanism of HCQ and other autophagy inhibitors are still required to answer questions surrounding how these agents will eventually be used in the clinic. äTargeting Autophagy in Cancer: Update on Clinical Trials and Novel Inh(epmc).pdf DeepDyve Pubget Overpricing