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2017 ; 18
(6
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among
Drugs, Viruses, and Immune System
#MMPMID28598363
Cho YT
; Yang CW
; Chu CY
Int J Mol Sci
2017[Jun]; 18
(6
): ä PMID28598363
show ga
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a
severe multiorgan hypersensitivity reaction mostly caused by a limited number of
eliciting drugs in patients with a genetic predisposition. Patients with DRESS
syndrome present with characteristic but variable clinical and pathological
features. Reactivation of human herpesviruses (HHV), especially HHV-6, is the
hallmark of the disease. Anti-viral immune responses intertwined with drug
hypersensitivity make the disease more complicated and protracted. In recent
years, emerging studies have outlined the disease more clearly, though several
important questions remain unresolved. In this review, we provide an overview of
DRESS syndrome, including clinical presentations, histopathological features,
pathomechanisms, and treatments.