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10.3390/ijms18061183 http://scihub22266oqcxt.onion/10.3390/ijms18061183 C5486006!5486006!28574430     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2017 ; 18 (6): ä Nephropedia Template TP {{tp|p=28574430|t=2017. Extracellular Vesicles in Hematological Malignancies: From Biology to Therapy |pdf=|usr=}}{{28574430}} gab.com Text Extracellular Vesicles in Hematological Malignancies: From Biology to Therapy JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28574430 #FOAvip Extracellular vesicles (EVs) are a heterogeneous group of particles, between 15 nanometers and 10 microns in diameter, released by almost all cell types in physiological and pathological conditions, including tumors. EVs have recently emerged as particularly interesting informative vehicles, so that they could be considered a true ?cell biopsy?. Indeed, EV cargo, including proteins, lipids, and nucleic acids, generally reflects the nature and status of the origin cells. In some cases, EVs are enriched of peculiar molecular cargo, thus suggesting at least a degree of specific cellular packaging. EVs are identified as important and critical players in intercellular communications in short and long distance interplays. Here, we examine the physiological role of EVs and their activity in cross-talk between bone marrow microenvironment and neoplastic cells in hematological malignancies (HMs). In these diseases, HM EVs can modify tumor and bone marrow microenvironment, making the latter ?stronger? in supporting malignancy, inducing drug resistance, and suppressing the immune system. Moreover, EVs are abundant in biologic fluids and protect their molecular cargo against degradation. For these and other ?natural? characteristics, EVs could be potential biomarkers in a context of HM liquid biopsy and therapeutic tools. These aspects will be also analyzed in this review. Twit Text FOAVip Extracellular Vesicles in Hematological Malignancies: From Biology to Therapy ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28574430 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28574430 #FOAvip English Wikipedia <ref>{{Cite pmid|28574430}}</ref> Extracellular Vesicles in Hematological Malignancies: From Biology to Therapy #MMPMID28574430 Caivano A; La Rocca F; Laurenzana I; Trino S; De Luca L; Lamorte D; Del Vecchio L; Musto P Int J Mol Sci 2017[Jun]; 18 (6): ä PMID28574430show ga Extracellular vesicles (EVs) are a heterogeneous group of particles, between 15 nanometers and 10 microns in diameter, released by almost all cell types in physiological and pathological conditions, including tumors. EVs have recently emerged as particularly interesting informative vehicles, so that they could be considered a true ?cell biopsy?. Indeed, EV cargo, including proteins, lipids, and nucleic acids, generally reflects the nature and status of the origin cells. In some cases, EVs are enriched of peculiar molecular cargo, thus suggesting at least a degree of specific cellular packaging. EVs are identified as important and critical players in intercellular communications in short and long distance interplays. Here, we examine the physiological role of EVs and their activity in cross-talk between bone marrow microenvironment and neoplastic cells in hematological malignancies (HMs). In these diseases, HM EVs can modify tumor and bone marrow microenvironment, making the latter ?stronger? in supporting malignancy, inducing drug resistance, and suppressing the immune system. Moreover, EVs are abundant in biologic fluids and protect their molecular cargo against degradation. For these and other ?natural? characteristics, EVs could be potential biomarkers in a context of HM liquid biopsy and therapeutic tools. These aspects will be also analyzed in this review. äExtracellular Vesicles in Hematological Malignancies: From Biology to (epmc).pdf DeepDyve Pubget Overpricing