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10.3390/ijms18061172

http://scihub22266oqcxt.onion/10.3390/ijms18061172
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C5485996!5485996!28561778
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suck abstract from ncbi


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pmid28561778      Int+J+Mol+Sci 2017 ; 18 (6): ä
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  • EZH2 in Cancer Progression and Potential Application in Cancer Therapy: A Friend or Foe? #MMPMID28561778
  • Yan KS; Lin CY; Liao TW; Peng CM; Lee SC; Liu YJ; Chan WP; Chou RH
  • Int J Mol Sci 2017[Jun]; 18 (6): ä PMID28561778show ga
  • Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 functions as a double-facet molecule in regulation of gene expression via repression or activation mechanisms, depending on the different cellular contexts. EZH2 interacts with both histone and non-histone proteins to modulate diverse physiological functions including cancer progression and malignancy. In this review article, we focused on the updated information regarding microRNAs (miRNAs) and long non coding RNAs (lncRNAs) in regulation of EZH2, the oncogenic and tumor suppressive roles of EZH2 in cancer progression and malignancy, as well as current pre-clinical and clinical trials of EZH2 inhibitors.
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