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10.3390/ijms18061138

http://scihub22266oqcxt.onion/10.3390/ijms18061138
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C5485962!5485962!28587102
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suck abstract from ncbi


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pmid28587102      Int+J+Mol+Sci 2017 ; 18 (6): ä
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  • Perturbations in the Replication Program Contribute to Genomic Instability in Cancer #MMPMID28587102
  • Blumenfeld B; Ben-Zimra M; Simon I
  • Int J Mol Sci 2017[Jun]; 18 (6): ä PMID28587102show ga
  • Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program.
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