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10.3390/ijms18061106 http://scihub22266oqcxt.onion/10.3390/ijms18061106 C5485930!5485930!28545226     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2017 ; 18 (6): ä Nephropedia Template TP {{tp|p=28545226|t=2017. Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis |pdf=|usr=}}{{28545226}} gab.com Text Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28545226 #FOAvip Colorectal cancer results from genetic aberrations which accumulate over a long period of time, with malignant and metastatic properties acquired at a relatively late stage. A subpopulation of CD26+ colorectal cancer stem cells are known to be implicated in metastasis. We quantified CD26+ cancer cells in 11 primary tumor samples by flow cytometry, and showed that tumors having confirmed or suspected metastases harbored a relatively high CD26+ level in these samples. We hypothesized that this subpopulation of cancer stem cells arises in the late stage of carcinogenesis from the bulk of tumor daughter cells which are CD26?. The manipulation of PIK3CA and TP53, two genes commonly deregulated in the late stage, had an effect on the maintenance of the CD26+ cell population. When CD26? tumor daughter cells were sorted and cultured, the emergence of tumor spheres containing CD26+ cells occurred. These findings shed light to the origin of colorectal cancer stem cells with metastatic properties, which has an implication on conventional treatments by surgery or adjuvant chemotherapy for tumor debulking. Twit Text FOAVip Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28545226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28545226 #FOAvip English Wikipedia <ref>{{Cite pmid|28545226}}</ref> Emergence of CD26+ Cancer Stem Cells with Metastatic Properties in Colorectal Carcinogenesis #MMPMID28545226 Cheung AHK; Iyer DN; Lam CSC; Ng L; Wong SKM; Lee HS; Wan T; Man J; Chow AKM; Poon RT; Pang R; Law WL Int J Mol Sci 2017[Jun]; 18 (6): ä PMID28545226show ga Colorectal cancer results from genetic aberrations which accumulate over a long period of time, with malignant and metastatic properties acquired at a relatively late stage. A subpopulation of CD26+ colorectal cancer stem cells are known to be implicated in metastasis. We quantified CD26+ cancer cells in 11 primary tumor samples by flow cytometry, and showed that tumors having confirmed or suspected metastases harbored a relatively high CD26+ level in these samples. We hypothesized that this subpopulation of cancer stem cells arises in the late stage of carcinogenesis from the bulk of tumor daughter cells which are CD26?. The manipulation of PIK3CA and TP53, two genes commonly deregulated in the late stage, had an effect on the maintenance of the CD26+ cell population. When CD26? tumor daughter cells were sorted and cultured, the emergence of tumor spheres containing CD26+ cells occurred. These findings shed light to the origin of colorectal cancer stem cells with metastatic properties, which has an implication on conventional treatments by surgery or adjuvant chemotherapy for tumor debulking. äEmergence of CD26+ Cancer Stem Cells with Metastatic Properties in Col(epmc).pdf DeepDyve Pubget Overpricing