Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28664185
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28664185
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 RNA+Dis
2017 ; 4
(2
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The miR-125a and miR-320c are potential tumor suppressor microRNAs epigenetically
silenced by the polycomb repressive complex 2 in multiple myeloma
#MMPMID28664185
Alzrigat M
; Jernberg-Wiklund H
RNA Dis
2017[]; 4
(2
): ä PMID28664185
show ga
We have previously presented the histone methyltransferase enhancer of zeste
homolog 2 (EZH2) of the polycomb repressive complex 2 (PRC2) as a potential
therapeutic target in Multiple Myeloma (MM). In a recent article in Oncotarget by
Alzrigat. et al. 2017, we have reported on the novel finding that EZH2 inhibition
using the highly selective inhibitor of EZH2 enzymatic activity, UNC1999,
reactivated the expression of microRNA genes previously reported to be
underexpressed in MM. Among these, we have identified miR-125a-3p and miR-320c as
potential tumor suppressor microRNAs as they were predicted to target
MM-associated oncogenes; IRF-4, XBP-1 and BLIMP-1. We also found EZH2 inhibition
to reactivate the expression of miR-494, a previously reported regulator of the
c-MYC oncogene. In addition, we could report that EZH2 inhibition downregulated
the expression of a few well described oncogenic microRNAs in MM. The data from
our recent article are here highlighted as it shed a new light onto the oncogenic
function of the PRC2 in MM. These data further strengthen the notion that the
PRC2 complex may be of potential therapeutic interest.
free
free
free
