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10.3390/nano7060120 http://scihub22266oqcxt.onion/10.3390/nano7060120 C5485767!5485767!28587119     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nanomaterials+(Basel) 2017 ; 7 (6): ä Nephropedia Template TP {{tp|p=28587119|t=2017. Trigger-Responsive Gene Transporters for Anticancer Therapy |pdf=|usr=}}{{28587119}} gab.com Text Trigger-Responsive Gene Transporters for Anticancer Therapy JO: Nanomaterials (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28587119 #FOAvip In the current era of gene delivery, trigger-responsive nanoparticles for the delivery of exogenous nucleic acids, such as plasmid DNA (pDNA), mRNA, siRNAs, and miRNAs, to cancer cells have attracted considerable interest. The cationic gene transporters commonly used are typically in the form of polyplexes, lipoplexes or mixtures of both, and their gene transfer efficiency in cancer cells depends on several factors, such as cell binding, intracellular trafficking, buffering capacity for endosomal escape, DNA unpacking, nuclear transportation, cell viability, and DNA protection against nucleases. Some of these factors influence other factors adversely, and therefore, it is of critical importance that these factors are balanced. Recently, with the advancements in contemporary tools and techniques, trigger-responsive nanoparticles with the potential to overcome their intrinsic drawbacks have been developed. This review summarizes the mechanisms and limitations of cationic gene transporters. In addition, it covers various triggers, such as light, enzymes, magnetic fields, and ultrasound (US), used to enhance the gene transfer efficiency of trigger-responsive gene transporters in cancer cells. Furthermore, the challenges associated with and future directions in developing trigger-responsive gene transporters for anticancer therapy are discussed briefly. Twit Text FOAVip Trigger-Responsive Gene Transporters for Anticancer Therapy ????Nanomaterials (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28587119 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28587119 #FOAvip English Wikipedia <ref>{{Cite pmid|28587119}}</ref> Trigger-Responsive Gene Transporters for Anticancer Therapy #MMPMID28587119 Rajendrakumar SK; Uthaman S; Cho CS; Park IK Nanomaterials (Basel) 2017[Jun]; 7 (6): ä PMID28587119show ga In the current era of gene delivery, trigger-responsive nanoparticles for the delivery of exogenous nucleic acids, such as plasmid DNA (pDNA), mRNA, siRNAs, and miRNAs, to cancer cells have attracted considerable interest. The cationic gene transporters commonly used are typically in the form of polyplexes, lipoplexes or mixtures of both, and their gene transfer efficiency in cancer cells depends on several factors, such as cell binding, intracellular trafficking, buffering capacity for endosomal escape, DNA unpacking, nuclear transportation, cell viability, and DNA protection against nucleases. Some of these factors influence other factors adversely, and therefore, it is of critical importance that these factors are balanced. Recently, with the advancements in contemporary tools and techniques, trigger-responsive nanoparticles with the potential to overcome their intrinsic drawbacks have been developed. This review summarizes the mechanisms and limitations of cationic gene transporters. In addition, it covers various triggers, such as light, enzymes, magnetic fields, and ultrasound (US), used to enhance the gene transfer efficiency of trigger-responsive gene transporters in cancer cells. Furthermore, the challenges associated with and future directions in developing trigger-responsive gene transporters for anticancer therapy are discussed briefly. äTrigger-Responsive Gene Transporters for Anticancer Therapy (epmc).pdf DeepDyve Pubget Overpricing